1-Bromo-2,3,5,6-tetramethylbenzene
1-Bromo-2,3,5,6-tetramethylbenzene (CAS: 1646-53-3) is a halogenated hydrocarbon with the molecular formula C10H13Br and a molecular weight of 213.11 g/mol. This organic building block is a key intermediate in chemical synthesis, particularly for creating more complex aromatic compounds. It is supplied by Tech Serve Solutions with a purity of 98%.
- IUPAC
- 3-Bromodurene
- Synonyms
- 3-Bromodurene1-Bromo-2,3,5,6-tetramethylbenzene

Synthesis of Dianhydride Monomers
1-Bromo-2,3,5,6-tetramethylbenzene serves as a precursor in the preparation of 1-(3′,5′-bis(trifluoromethyl)phenyl)pyromellitic dianhydride, a mono-substituted dianhydride monomer used in polymer chemistry.
Borane Chemistry
This compound is utilised in the synthesis of various organoboron compounds, including 2-(N,N-dimethylamino)phenylbis(2,3,5,6-tetramethylphenyl)borane and 2-(N,N-diethylamino)phenyl-2,3,5,6-tetramethylphenylborinic acid.
Acrylamide Derivatives
It has been employed in the synthesis of 3-(2,3,5,6-tetramethylphenyl)acrylamide, a substituted acrylamide with potential applications in materials science or organic synthesis.
| Molecular weight | 213.11 |
|---|---|
| Linear formula | HC6(CH3)4Br |
| Assay | 98% |
| Boiling point | 111-113 °C/6 mmHg(lit.) |
| Application | 1-Bromo-2,3,5,6-tetramethylbenzene has been used in the preparation of:• 1-(3′,5′-bis(trifluoromethyl)phenyl)pyromellitic dianhydride, mono-substituted dianhydride monomer1• 2-(N,N-dimethylamino)phenylbis(2,3,5,6-tetramethylphenyl)borane2• 2-(N,N-diethylamino)phenyl-2,3,5,6-tetramethylphenylborinic acid2• 3-(2,3,5,6-tetramethylphenyl)acrylamide3. |
| Melting point | 60-62 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bromo-2,3,5,6-tetramethylbenzene used for?
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1-Bromo-2,3,5,6-tetramethylbenzene is used as an intermediate in chemical synthesis, particularly for preparing substituted dianhydrides, boranes, and acrylamides.
What are the CAS number and molecular formula for 1-Bromo-2,3,5,6-tetramethylbenzene?
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The CAS number is 1646-53-3 and the molecular formula is C10H13Br.
What grade and purity does Tech Serve Solutions supply for 1-Bromo-2,3,5,6-tetramethylbenzene?
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Tech Serve Solutions supplies 1-Bromo-2,3,5,6-tetramethylbenzene with an assay of 98%. This is a technical grade material and is not represented as USP, BP, or EP.
How should 1-Bromo-2,3,5,6-tetramethylbenzene be handled safely?
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1-Bromo-2,3,5,6-tetramethylbenzene is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). It requires appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
Is 1-Bromo-2,3,5,6-tetramethylbenzene available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 1-Bromo-2,3,5,6-tetramethylbenzene.
How can I request a quote or sample of 1-Bromo-2,3,5,6-tetramethylbenzene?
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Please contact our sales team via the website or by phone to request a quote or a sample of 1-Bromo-2,3,5,6-tetramethylbenzene.
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