1-Boc-4-hydroxypiperidine
1-Boc-4-hydroxypiperidine (CAS: 109384-19-2, C10H19NO3) is a versatile N-Boc protected piperidine derivative with a molecular weight of 201.26 g/mol. This compound serves as a valuable chiral building block in organic synthesis. It is specifically noted for its utility in the formation of N-heterocyclic alkyl ethers through the Mitsunobu reaction, contributing to the construction of complex molecular architectures in pharmaceutical and chemical research.
- IUPAC
- 1-Boc-4-piperidinol,tert-Butyl 4-hydroxy-1-piperidinecarboxylate
- Synonyms
- tert-Butyl 4-hydroxy-1-piperidinecarboxylate
Synthesis of N-Heterocyclic Alkyl Ethers
This compound is employed in the synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction. This application is crucial for building complex molecular scaffolds in medicinal chemistry and organic synthesis research.
Chiral Building Block
As a chiral building block, 1-Boc-4-hydroxypiperidine is instrumental in asymmetric synthesis. It facilitates the introduction of a functionalised piperidine ring with defined stereochemistry into target molecules.
Heterocyclic Chemistry
It serves as a key intermediate in the synthesis of various substituted piperidine derivatives. Its structure is fundamental for constructing more complex heterocyclic compounds.
| Molecular weight | 201.26 |
|---|---|
| Empirical formula | C10H19NO3 |
| Assay | 97% |
| Application | Used in a synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction.1 |
| Melting point | 61-65 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Boc-4-hydroxypiperidine used for?
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1-Boc-4-hydroxypiperidine is primarily used in organic synthesis as a chiral building block, particularly for the preparation of N-heterocyclic alkyl ethers via the Mitsunobu reaction.
What are the CAS number and formula for 1-Boc-4-hydroxypiperidine?
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The CAS number for 1-Boc-4-hydroxypiperidine is 109384-19-2, and its empirical formula is C10H19NO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Boc-4-hydroxypiperidine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 1-Boc-4-hydroxypiperidine be handled?
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1-Boc-4-hydroxypiperidine is a Warning substance (GHS07) and is classified with hazards H315, H319, and H335. It can cause skin, eye, and respiratory irritation. Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used when handling. Ensure adequate ventilation.
Is 1-Boc-4-hydroxypiperidine a controlled substance?
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The provided data does not indicate that 1-Boc-4-hydroxypiperidine is a controlled substance.
How is 1-Boc-4-hydroxypiperidine packed and shipped?
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1-Boc-4-hydroxypiperidine is packed securely for transit and is available for global export. Please contact us for specific shipping and export details.
How can I request a sample or quote?
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To request a sample or a quote for 1-Boc-4-hydroxypiperidine, please use the contact form on our website or call our sales department.
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