1-Boc-2-aminomethylpiperidine
1-Boc-2-aminomethylpiperidine (CAS: 370069-31-1; Formula: C11H22N2O2; MW: 214.30) is a heterocyclic building block. This protected piperidine derivative serves as a key reactant in complex organic synthesis. Its applications include the preparation of TRPV1 antagonists, CHK1 inhibitors, and p38a MAP kinase inhibitors. It is also utilised in the synthesis of carbamoylphosphonates and macrolactams via carbonylation and intramolecular amidation processes.
- IUPAC
- 1,1-Dimethylethyl 2-(aminomethyl)-1-piperidinecarboxylate,2-Aminomethylpiperidine-1-carboxylic acid tert-butyl ester
Synthesis of TRPV1 Antagonists
1-Boc-2-aminomethylpiperidine is employed as a reactant in the synthesis of TRPV1 antagonists, which are investigated for various therapeutic applications.
Preparation of CHK1 Inhibitors
This compound is a valuable building block for constructing CHK1 inhibitors, agents of interest in cancer research and treatment strategies.
Development of p38a MAP Kinase Inhibitors
Researchers utilise 1-Boc-2-aminomethylpiperidine in the synthetic pathways leading to p38a MAP kinase inhibitors, targeting inflammatory responses.
Formation of Carbamoylphosphonates
The molecule acts as a precursor in the synthesis of carbamoylphosphonates, a class of compounds with potential applications in medicinal chemistry.
Macrolactam Synthesis
1-Boc-2-aminomethylpiperidine facilitates the formation of macrolactams through carbonylation and subsequent intramolecular amidation reactions.
| Molecular weight | 214.30 |
|---|---|
| Empirical formula | C11H22N2O2 |
| Assay | 95% |
| Density | 1.0124 g/mL at 25 °C |
| Refractive index | n20/D 1.4745 |
| Application | Reactant for synthesis of:• TRPV1 antagonists1• CHK1 inhibitors2• p38a MAP kinase inhibitors3• Carbamoylphosphonates4• Macrolactams via carbonylation/intramolecular amidation5• Intramolecular transamidation6 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 3082 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-36/37/38-50 |
| Safety statements (S) | 26-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Boc-2-aminomethylpiperidine used for?
+
1-Boc-2-aminomethylpiperidine is primarily used as a reactant and building block in organic synthesis, particularly for the preparation of TRPV1 antagonists, CHK1 inhibitors, p38a MAP kinase inhibitors, carbamoylphosphonates, and macrolactams.
What are the CAS number and molecular formula for 1-Boc-2-aminomethylpiperidine?
+
The CAS number is 370069-31-1, and the molecular formula is C11H22N2O2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1-Boc-2-aminomethylpiperidine with an assay of 95%. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
What are the main safety hazards associated with 1-Boc-2-aminomethylpiperidine?
+
1-Boc-2-aminomethylpiperidine is classified with GHS07 and GHS09 symbols, and a Warning signal word. It carries hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), and H400 (Very toxic to aquatic life). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, should be used.
Is 1-Boc-2-aminomethylpiperidine suitable for export and international shipping?
+
Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 1-Boc-2-aminomethylpiperidine, which can be shipped internationally. It is classified under UN 3082, 9, PG III.
How can I request a quote or sample for 1-Boc-2-aminomethylpiperidine?
+
To request a quote or a sample of 1-Boc-2-aminomethylpiperidine, please contact the TSS sales department through the website or by phone, providing your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis