1,5,5-Trimethylhydantoin
1,5,5-Trimethylhydantoin (CAS: 6851-81-6), with the molecular formula C6H10N2O2 and a molecular weight of 142.16 g/mol, is a versatile heterocyclic compound. It serves as a key reactant in various organic syntheses, notably in the development of selective inhibitors for biological targets and in stereoselective addition reactions. Available from Tech Serve Solutions, this compound is supplied with a purity of 98%.
- IUPAC
- 1,5,5-Trimethyl-2,4-imidazolidinedione,3,4,4-Trimethyl-2,5-dioxoimidazolidine
- Synonyms
- 6851-81-6C6H10N2O21,5,5-Trimethyl-2,4-imidazolidinedione3,4,4-Trimethyl-2,5-dioxoimidazolidine
Z-Selective Hydroamidation
1,5,5-Trimethylhydantoin acts as a reactant in the Z-selective hydroamidation of terminal alkynes with secondary amides and imides, a valuable transformation in synthetic organic chemistry.
Hepatitis C Virus NS3 Protease Inhibitors
This compound is employed in the synthesis of selective inhibitors targeting the hepatitis C virus NS3 serine protease, contributing to antiviral research and development.
Stereoselective Alkyne Additions
It facilitates the stereoselective addition of imides to alkynes, enabling precise control over stereochemistry in complex molecular constructions.
Angiotensin II AT2 Receptor Agonists
1,5,5-Trimethylhydantoin is utilized in the synthesis of selective angiotensin II AT2 receptor agonists designed with reduced CYP 450 inhibition.
N-Chlorohydantoin Synthesis
The compound serves as a precursor for the preparation of N-chlorohydantoins, which find applications in various chemical processes.
P2X7 Receptor Antagonists
It is a reactant in the synthesis pathways leading to P2X7 receptor antagonists, compounds of interest in pharmacological research.
| Molecular weight | 142.16 |
|---|---|
| Empirical formula | C6H10N2O2 |
| Assay | 98% |
| Application | Reactant for: Z-selective hydroamidation of terminal alkynes with secondary amides and imides1 Selective inhibitors of hepatitis C virus NS3 serine protease2 Stereoselective addition of imides to alkynes3 Reactant for synthesis of: Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition4 N-chlorohydantoins5 P2X7 receptor antagonists6 |
| Melting point | 161-164 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,5,5-Trimethylhydantoin used for?
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1,5,5-Trimethylhydantoin is used as a reactant in various organic syntheses, including the preparation of Z-selective hydroamidations, inhibitors of hepatitis C virus NS3 serine protease, stereoselective imide additions to alkynes, selective angiotensin II AT2 receptor agonists, N-chlorohydantoins, and P2X7 receptor antagonists.
What is the CAS number and molecular formula for 1,5,5-Trimethylhydantoin?
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The CAS number for 1,5,5-Trimethylhydantoin is 6851-81-6, and its molecular formula is C6H10N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,5,5-Trimethylhydantoin with an assay of 98%. This is a technical/research grade material and is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 1,5,5-Trimethylhydantoin be handled safely?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Ensure good ventilation. Avoid breathing dust. This compound is classified as causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335), requiring careful handling.
Is 1,5,5-Trimethylhydantoin a controlled substance?
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The provided data does not indicate that 1,5,5-Trimethylhydantoin is a controlled substance.
How is 1,5,5-Trimethylhydantoin packaged and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging for the safe handling, storage, and international shipment of 1,5,5-Trimethylhydantoin.
How can I request a quote or sample for 1,5,5-Trimethylhydantoin?
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To request a quote or sample of 1,5,5-Trimethylhydantoin, please contact our sales team through the website or directly via email, providing your specific requirements.
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