1,4-Dimethoxy-2-butyne
1,4-Dimethoxy-2-butyne (CAS: 16356-02-8) is an organic compound with the molecular formula CH3OCH2C≡CCH2OCH3 and a molecular weight of 114.14 g/mol. This disubstituted alkyne features methoxy groups, offering unique reactivity for organic synthesis. It is primarily utilised as a building block in the construction of more complex molecular architectures within chemical research and development.
- Synonyms
- CH3OCH2C≡CCH2OCH3

Organic Synthesis Intermediate
Serves as a valuable intermediate in the synthesis of diverse organic molecules. Its alkyne functionality can participate in various addition and cycloaddition reactions.
Building Block for Complex Molecules
Utilised as a fundamental building block in the design and synthesis of novel compounds, particularly in medicinal chemistry and materials science research.
Research and Development
Employed in academic and industrial research laboratories for exploring new synthetic pathways and developing innovative chemical entities.
| Molecular weight | 114.14 |
|---|---|
| Linear formula | CH3OCH2C≡CCH2OCH3 |
| Assay | 97% |
| Boiling point | 70 °C/30 mmHg(lit.) |
| Density | 0.944 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.434(lit.) |

Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 53 °C / 127.4 °F |
| Transport (UN / ADR) | UN 3271 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,4-Dimethoxy-2-butyne used for?
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1,4-Dimethoxy-2-butyne is primarily used as an intermediate and building block in organic synthesis for research and development purposes.
What is the CAS number and formula for 1,4-Dimethoxy-2-butyne?
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The CAS number is 16356-02-8 and the linear formula is CH3OCH2C≡CCH2OCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,4-Dimethoxy-2-butyne with an assay of 97%. This product is intended for research and technical use and is not represented as USP, BP, or EP grade.
How should 1,4-Dimethoxy-2-butyne be handled?
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1,4-Dimethoxy-2-butyne is a flammable liquid and vapour (H226). Handle in a well-ventilated area, away from ignition sources. Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, should be used.
How is this chemical packed and shipped?
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This chemical is packed and shipped according to relevant transportation regulations, including UN 3271, Class 3, Packing Group III.
How can I request a quote or sample?
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Please contact our sales team via the website or direct email to request a quotation or sample of 1,4-Dimethoxy-2-butyne.
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