1,4-Difluorobenzene
1,4-Difluorobenzene (CAS 540-36-3), with the molecular formula C6H4F2 and a molecular weight of 114.09 g/mol, is a fluorinated aromatic compound. It serves as a valuable building block in organic synthesis. Its key applications lie in the development of pharmaceuticals, agrochemicals, and advanced materials, owing to the unique properties imparted by the fluorine atoms. This chemical is supplied by TSS with an assay of ≥99%.
- Synonyms
- Benzene, 1,4-difluoro-p-DifluorobenzeneC6H4F2
Pharmaceutical Intermediate
1,4-Difluorobenzene is utilised as a key intermediate in the synthesis of various active pharmaceutical ingredients (APIs). The presence of fluorine can significantly influence a drug's metabolic stability, lipophilicity, and binding affinity.
Agrochemical Synthesis
This compound finds application in the development of novel agrochemicals, including herbicides, insecticides, and fungicides. The difluorobenzene moiety can enhance the efficacy and persistence of crop protection agents.
Materials Science
It is employed in the synthesis of advanced materials, such as liquid crystals and polymers. The electronic properties of the aromatic ring, modified by fluorine substitution, are beneficial in these applications.
Organic Synthesis Building Block
As a versatile organic building block, 1,4-Difluorobenzene is a precursor for introducing the difluorophenyl group into more complex molecules across various research and industrial fields.
| Molecular weight | 114.09 |
|---|---|
| Empirical formula | C6H4F2 |
| Assay | ≥99% |
| Boiling point | 88-89 °C(lit.) |
| Density | 1.11 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.441(lit.) |
| Melting point | −13 °C(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 2 °C / 35.6 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-20 |
| Safety statements (S) | 16-29-33 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,4-Difluorobenzene used for?
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1,4-Difluorobenzene is primarily used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced materials, and as a general building block in organic chemistry.
What is the CAS number and molecular formula for 1,4-Difluorobenzene?
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The CAS number is 540-36-3 and the molecular formula is C6H4F2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,4-Difluorobenzene with a minimum assay of 99%. We do not represent this product as USP, BP, or EP grade.
What are the primary safety concerns when handling 1,4-Difluorobenzene?
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1,4-Difluorobenzene is a flammable liquid and vapour (H225). It requires careful handling, including storage away from ignition sources, use of appropriate personal protective equipment such as eyeshields and gloves, and adequate ventilation.
How is 1,4-Difluorobenzene packed and exported?
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This chemical is packed and shipped according to international regulations for hazardous materials, including UN 1993 classification. TSS is experienced in global export.
How can I request a sample or quote for 1,4-Difluorobenzene?
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Please contact our sales team via the website or phone to request a sample or a formal quotation for 1,4-Difluorobenzene.
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