1,2:5,6-Di-O-isopropylidene-D-mannitol
1,2:5,6-Di-O-isopropylidene-D-mannitol (CAS 1707-77-3) is a protected carbohydrate derivative with the molecular formula C12H22O6 and a molecular weight of 262.30 g/mol. This compound is valuable in carbohydrate chemistry and chemical synthesis due to its protected diol functionalities. It serves as a chiral building block in the synthesis of complex organic molecules and pharmaceutical intermediates, offering a defined stereochemical pathway.
- IUPAC
- D-Mannitol diacetonide
- Synonyms
- 1707-77-3D-Mannitol diacetonide1,2:5,6-Diacetonyl-D-mannitol

Chiral Building Block
Utilised as a chiral starting material in asymmetric synthesis for the creation of complex organic molecules, including pharmaceuticals and natural products.
Carbohydrate Derivative Synthesis
Serves as a precursor for the synthesis of various modified carbohydrates and complex glycoconjugates in research and development settings.
Protecting Group Chemistry
The isopropylidene groups act as effective protecting groups for the diols of D-mannitol, enabling selective reactions at other sites of the molecule.
Intermediate in Organic Synthesis
Employed as a key intermediate in multi-step synthetic routes requiring a D-mannitol-derived scaffold with specific stereochemical control.
| Molecular weight | 262.30 |
|---|---|
| Empirical formula | C12H22O6 |
| Assay | 98% |
| Grade | purum |
| Optical activity | [α]/D +6.0±1.0°, c = 5 in chloroform |
| Melting point | 120-122 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,2:5,6-Di-O-isopropylidene-D-mannitol used for?
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This compound is primarily used as a chiral building block in organic synthesis, particularly in carbohydrate chemistry and the preparation of complex molecules and pharmaceutical intermediates.
What is the CAS number and formula for 1,2:5,6-Di-O-isopropylidene-D-mannitol?
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The CAS number is 1707-77-3, and the empirical formula (Hill notation) is C12H22O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,2:5,6-Di-O-isopropylidene-D-mannitol with an assay of 98% and a 'purum' grade. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for this chemical?
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Handle with care, using appropriate personal protective equipment including eyeshields, gloves, and a suitable respirator filter (type N95 or P1). Consult the safety data sheet for detailed hazard information. The German Water Hazard Class (WGK) is 3.
How is 1,2:5,6-Di-O-isopropylidene-D-mannitol packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals globally in compliance with all relevant regulations, ensuring product integrity and safety during transit.
How can I request a sample or quote for 1,2:5,6-Di-O-isopropylidene-D-mannitol?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (1707-77-3).
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