1,1′-Carbonyldiimidazole solution
1,1′-Carbonyldiimidazole (CAS 530-62-1) is a versatile reagent with the molecular formula C7H6N4O and a molecular weight of 162.15 g/mol. Supplied as a 0.4 M solution in methylene chloride, it serves as an effective coupling agent and is widely employed in chemical synthesis for activating carboxylic acids and forming esters, amides, and other derivatives. Its ability to facilitate challenging bond formations makes it valuable in various research and development applications.
- Synonyms
- 1,1'-CarbonyldiimidazoleCDICarbonyl diimidazole
Peptide Synthesis
1,1′-Carbonyldiimidazole is a common reagent for activating amino acids, facilitating peptide bond formation in both solution and solid-phase synthesis. It reacts readily with carboxylic acids to form activated imidazolides, which are then susceptible to nucleophilic attack by amines.
Ester and Amide Formation
This compound is extensively used for the synthesis of esters and amides from carboxylic acids and alcohols or amines, respectively. It provides a mild and efficient method for acylation reactions, often yielding high product purity.
Heterocyclic Synthesis
1,1′-Carbonyldiimidazole can be employed in the construction of various heterocyclic ring systems. Its reactivity allows for cyclisation reactions and the introduction of carbonyl functionalities into organic frameworks.
Reagent for Chemical Synthesis
As a general synthetic reagent, it is valuable for activating alcohols and amines, forming carbamates, and enabling diverse chemical transformations in organic chemistry research and development.
| Molecular weight | 162.15 |
|---|---|
| Empirical formula | C7H6N4O |
| Assay | ≥95.0% (T) |
| Density | 1.303 g/mL at 25 °C |
| Refractive index | n20/D 1.434 |
| Concentration | 0.4 M in methylene chloride |
| Storage temperature | 2-8°C |
| Melting point | 115-122 °C117-122 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H351Suspected of causing cancer
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2922 8/PG 3 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/38-40 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,1′-Carbonyldiimidazole solution used for?
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1,1′-Carbonyldiimidazole solution (CAS 530-62-1) is primarily used as a coupling agent in chemical synthesis, particularly for activating carboxylic acids to form esters and amides, and in peptide synthesis.
What is the CAS number and molecular formula for 1,1′-Carbonyldiimidazole solution?
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The CAS number is 530-62-1, and the molecular formula is C7H6N4O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,1′-Carbonyldiimidazole solution with an assay of ≥95.0% (T). TSS does not represent this product as USP, BP, or EP grade.
How should 1,1′-Carbonyldiimidazole solution be handled safely?
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This product is classified as corrosive and may cause long-term health effects. Handle with appropriate personal protective equipment, including eyeshields, faceshields, and gloves. Ensure adequate ventilation and avoid contact with skin, eyes, and clothing. Refer to the Safety Data Sheet for detailed handling procedures.
How is 1,1′-Carbonyldiimidazole solution shipped and exported?
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1,1′-Carbonyldiimidazole solution is shipped and exported in compliance with international regulations for hazardous materials, including UN 2922, Class 8, Packing Group 3.
How can I request a sample or quote for 1,1′-Carbonyldiimidazole solution?
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To request a sample or a quote, please contact our sales department through the website or by phone, providing the product name and CAS number.
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