1,1,3,3-Tetramethoxycyclobutane
1,1,3,3-Tetramethoxycyclobutane (CAS: 152897-19-3; Formula: C4H4(OCH3)4) is a chemical compound with a molecular weight of 176.21 g/mol. This acetal/ketal is a valuable organic building block utilised in chemical synthesis. It serves as a versatile intermediate in the production of more complex molecules, offering a unique cyclobutane core with protected carbonyl functionalities.
- IUPAC
- 1,3-Cyclobutanedione bis(dimethyl acetal)
- Synonyms
- 3-Tetramethoxycyclobutane152897-19-3C4H4(OCH3)41,3-Cyclobutanedione bis(dimethyl acetal)

Organic Synthesis Intermediate
1,1,3,3-Tetramethoxycyclobutane is employed as a key building block in multi-step organic syntheses. Its structure allows for selective transformations, making it useful in constructing complex molecular frameworks.
Protected Cyclobutane Derivative
The compound serves as a stable source of the cyclobutane-1,3-dione moiety, protected as its dimethyl acetal. This protection strategy is crucial for carrying out reactions on other parts of a molecule without affecting the latent dicarbonyl system.
Research and Development
Utilised in research laboratories for exploring new synthetic routes and developing novel chemical entities. Its specific structural features make it of interest for academic and industrial R&D projects.
| Molecular weight | 176.21 |
|---|---|
| Linear formula | C4H4(OCH3)4 |
| Assay | 99% |
| Boiling point | 49 °C/0.75 mmHg(lit.) |
| Density | 1.032 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.425(lit.) |

Hazard statements
- H226Flammable liquid and vapour
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 37 °C / 98.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Risk statements (R) | 10 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,1,3,3-Tetramethoxycyclobutane used for?
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1,1,3,3-Tetramethoxycyclobutane is primarily used as a building block and intermediate in organic synthesis, particularly for constructing complex molecular frameworks and as a protected form of cyclobutane-1,3-dione.
What are the CAS number and chemical formula for 1,1,3,3-Tetramethoxycyclobutane?
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The CAS number is 152897-19-3, and the chemical formula is C4H4(OCH3)4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,1,3,3-Tetramethoxycyclobutane with a purity of 99%. This is a technical/research grade product, and TSS does not represent it as USP, BP, or EP.
What are the main safety hazards associated with 1,1,3,3-Tetramethoxycyclobutane?
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1,1,3,3-Tetramethoxycyclobutane is a flammable liquid and vapour (H226), indicated by a 'Warning' signal word and GHS02 symbol. Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, should be used.
How is 1,1,3,3-Tetramethoxycyclobutane packed and shipped?
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1,1,3,3-Tetramethoxycyclobutane is packed and shipped according to UN 1993 regulations for flammable liquids (C3/PGIII), ensuring safe transport and export.
How can I request a sample or quote for 1,1,3,3-Tetramethoxycyclobutane?
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To request a sample or obtain a quote for 1,1,3,3-Tetramethoxycyclobutane, please contact the Tech Serve Solutions sales team through our website or designated contact channels.
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