1,1,2,2-Tetrafluoroethanesulfonic acid
1,1,2,2-Tetrafluoroethanesulfonic acid (CAS 464-14-2), with the molecular formula CHF2CF2SO3H and a molecular weight of 182.09, is a specialised fluorinated organic building block. It serves as a potent acid catalyst and is noted as an alternative to triflic acid in various chemical syntheses. Its unique properties make it valuable for reactions requiring strong acidic conditions and high thermal stability.
- IUPAC
- TFESA
- Synonyms
- 2-Tetrafluoroethanesulfonic acid464-14-2CHF2CF2SO3H
Acid Catalysis in Organic Synthesis
This compound functions as a strong acid catalyst, useful in promoting a range of organic transformations. Its fluorinated structure can offer unique reactivity and stability profiles compared to non-fluorinated analogues.
Alternative to Triflic Acid
1,1,2,2-Tetrafluoroethanesulfonic acid is recognised as a viable alternative to triflic acid (CF3SO3H). This substitution can be advantageous in specific synthetic routes where differing steric or electronic properties are desired.
Fluorinated Building Block
As a fluorinated organic building block, it is employed in the synthesis of complex molecules where the incorporation of fluoroalkyl groups is critical for modifying properties such as lipophilicity, metabolic stability, or electronic characteristics.
| Molecular weight | 182.09 |
|---|---|
| Linear formula | CHF2CF2SO3H |
| Assay | 97% |
| Boiling point | 210-211 °C/760 mmHg |
| Density | 1.747 g/mL at 25 °C |
| Refractive index | n20/D 1.354 |
| Application | Alternative to triflic acid.1 |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 21/22-35 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,1,2,2-Tetrafluoroethanesulfonic acid used for?
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1,1,2,2-Tetrafluoroethanesulfonic acid is primarily used as a strong acid catalyst in organic synthesis and as a fluorinated building block for creating complex molecules. It is also noted as an alternative to triflic acid.
What are the CAS number and chemical formula for 1,1,2,2-Tetrafluoroethanesulfonic acid?
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The CAS number for 1,1,2,2-Tetrafluoroethanesulfonic acid is 464-14-2, and its chemical formula is CHF2CF2SO3H.
What grade and purity does Tech Serve Solutions supply for 1,1,2,2-Tetrafluoroethanesulfonic acid?
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Tech Serve Solutions supplies 1,1,2,2-Tetrafluoroethanesulfonic acid with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 1,1,2,2-Tetrafluoroethanesulfonic acid be handled?
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1,1,2,2-Tetrafluoroethanesulfonic acid is classified as Danger. It is harmful if swallowed, harmful in contact with skin, and causes severe skin burns and eye damage. Appropriate personal protective equipment, including gloves, goggles, a faceshield, and a suitable respirator, must be worn. Handle with extreme care in a well-ventilated area.
How is 1,1,2,2-Tetrafluoroethanesulfonic acid packed and shipped?
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As a chemical supplier, Tech Serve Solutions ensures that 1,1,2,2-Tetrafluoroethanesulfonic acid is packed and shipped in accordance with all relevant national and international regulations for hazardous materials, including UN 3265, Class 8, Packing Group I.
How can I request a sample or a quote for 1,1,2,2-Tetrafluoroethanesulfonic acid?
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To request a sample or obtain a quote for 1,1,2,2-Tetrafluoroethanesulfonic acid, please contact our sales department through the website or by phone. Our team will be pleased to assist you.
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