1,1,1-Trifluoro-2-iodoethane
1,1,1-Trifluoro-2-iodoethane (CAS: 353-83-3) is a halogenated organic compound with the molecular formula CF3CH2I and a molecular weight of 209.94 g/mol. This clear, colourless liquid serves as a valuable building block in organic synthesis. Its unique structure, featuring a trifluoromethyl group and an iodine atom, makes it useful for introducing fluorinated ethyl moieties into various molecules, particularly in pharmaceutical and agrochemical research.
- IUPAC
- 2,2,2-Trifluoroethyl iodide,2-Iodo-1,1,1-trifluoroethane
- Synonyms
- 353-83-3CF3CH2I2,2,2-Trifluoroethyl iodide2-Iodo-1,1,1-trifluoroethane

Organic Synthesis Reagent
Used as a precursor in the synthesis of more complex organic molecules. The iodine atom readily participates in nucleophilic substitution and coupling reactions.
Fluorinated Compound Synthesis
Enables the introduction of the 2,2,2-trifluoroethyl group, a common motif in pharmaceuticals and agrochemicals, into target molecules.
Research and Development
Employed in academic and industrial research laboratories for exploring novel chemical transformations and developing new materials or drug candidates.
| Molecular weight | 209.94 |
|---|---|
| Linear formula | CF3CH2I |
| Assay | 99% |
| Boiling point | 54.8 °C(lit.) |
| Density | 2.13 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.401(lit.) |
| Vapour pressure | 3.96 psi (20 °C) |
| Contains / stabiliser | copper as stabilizer |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US) |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,1,1-Trifluoro-2-iodoethane used for?
+
1,1,1-Trifluoro-2-iodoethane is primarily used as a building block in organic synthesis, especially for introducing the 2,2,2-trifluoroethyl group into molecules for pharmaceutical and agrochemical research and development.
What is the CAS number and formula for 1,1,1-Trifluoro-2-iodoethane?
+
The CAS number for 1,1,1-Trifluoro-2-iodoethane is 353-83-3, and its linear formula is CF3CH2I.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1,1,1-Trifluoro-2-iodoethane with an assay of 99%. This is a technical/research grade chemical, and TSS does not represent it as USP, BP, or EP grade.
How should 1,1,1-Trifluoro-2-iodoethane be handled safely?
+
1,1,1-Trifluoro-2-iodoethane is a warning-hazardous substance (GHS07). It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be worn, and work should be conducted in a well-ventilated area or fume hood. Refer to the safety data sheet for comprehensive guidance.
Is 1,1,1-Trifluoro-2-iodoethane a controlled substance?
+
The provided data does not indicate that 1,1,1-Trifluoro-2-iodoethane is a controlled substance.
How is this chemical packed and exported?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, ensuring appropriate packaging and documentation for international shipment in compliance with regulations.
How can I request a sample or quote?
+
Please contact our sales department through the website or by phone to request a sample or obtain a quotation for 1,1,1-Trifluoro-2-iodoethane.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis