Applications

Benzotriazole amino acids, or aminoacylbenzotriazolides, are versatile reagents for synthesizing peptides as well as their mimetics and conjugates. Benzotriazole amino acids have been used for the preparation of diverse derivatives including:

• Polypeptidal benzotriazolides¹
• Peptidomimetics, such as aminoxypeptides², depsipeptides³ and heterocyclic peptidomimetics⁴
• Tagged peptides and peptidomimetics, particularly those with fluorescent labels^5,6
• N, O, S, and C linked peptide conjugates⁶