Applications

A water-tolerant Lewis acid catalyst recently used in one-pot syntheses of β-lactams,² and in stereocontrolled radical³ and nucleophilic¹ addition reactions. Catalyzes the synthesis of deoxypenostatin A in a novel, stereoselective, intramolecular Diels-Alder reaction.⁴
Lewis acid catalyst used with a silylated chinchona alkaloid in an asymmetric synthesis of substituted β-lactams from an acid chloride and aryl imine.⁵ Also used to catalyze an aldehyde-ene reaction in a synthesis of the guaiane skeleton.⁶
An important Lewis acid catalyst for a variety of synthetic reactions, including allylborations.^7,8