Applications

5-Amino-4,6-dichloropyrimidine was used in the synthesis of:
• oxepane ring containing monocyclic, conformationally restricted bicyclic and spirocyclic nucleosides¹
• conformationally locked bicyclo[2.2.1]heptane/oxa-bicyclo[3.2.1]octane nucleosides²
• N(7)-substituted purines³
• chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine⁴
• 9-alkyl-6-substituted-purine analogs, potent anticonvulsant agents⁵
• pyrimido-oxazepines in a three-step process with microwave heating at 150°C⁶