Applications

Reactant for preparation of:
• Inhibitors of mammalian target of rapamycin (mTOR ) protein¹
• Inhibitors of the AcrAB-TolC efflux pump²
• Inhibitors of Gli1-mediated transcription in the Hedgehog pathway³
• Potent DNA-topoisomerase II poisons and anti-MDR agents⁴
• Protein kinase C θ (PKCθ) inhibitors⁵
• Piperidine carboxamide as transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists⁶
• Potent and selective blockers of the Nav1.8 sodium channel as potential analgesics for the treatment of neuropathic and inflammatory pain⁷
• 5,6-fused heteroaromatic ureas as TRPV1 antagonists⁸
• Allosteric enhancers of the A3 adenosine receptor⁹
• Human liver glycogen phosphorylase (HLGP) inhibitors for the treatment of type 2 d