Applications

3-Chloro-2,4(3H,5H)-furandione (3-Chlorotetronic acid) is a C₄-heterocyclic building block and has been used in synthesis of:
• pure tetronic acid¹
• pyridinium-, isoquinolinium-, quinolinium- and N-methyl imidazolium zwitterions²
• pyridine-, isoquinoline-, quinoline- and N-methylimidazole ylides²
• rubrolide L, a marine ascidian butenolide and a potent inhibitor of human aldose reductase³