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Diethyl (1-cyanoethyl)phosphonate

Diethyl (1-cyanoethyl)phosphonate chemical structure
CAS Number29668-61-9
FormulaCH3CH(CN)P(O)(OC2H5)2
Mol. Weight191.16 g/mol

What is Diethyl (1-cyanoethyl)phosphonate?

Diethyl (1-cyanoethyl)phosphonate is a chemical compound with CAS number 29668-61-9 and molecular formula CH3CH(CN)P(O)(OC2H5)2. It is used in various industrial and research applications.

Applications

Reacant for:
• Preparation of sphingosine phosphate receptor (S1P) agonists with N-cinnamyl-ß-alanine moiety1
• Preparation of benzyl- and benzoyldimethylaminopyridinones as HIV-1 reverse transcriptase inhibitors2
• Stereoselective preparation of cyano(trifluoromethyl)pentenenitriles via alkylation, followed by elimination reaction3
• Synthesis of [(methylenepiperidinyl) or (methylenepyrrolidinyl)fluorophenyl]oxazolidinone antibacterial agents4
• Horner-Wadsworth-Emmons olefination5

Specifications

Linear Formula

CH3CH(CN)P(O)(OC2H5)2

Molecular Weight

191.16 g/mol

Assay/Purity

97%

Boiling Point

140-141 °C/11 mmHg(lit.)

Density

1.085 g/mL at 25 °C(lit.)

Safety Information

GHS07GHS07
Signal Word

Warning

Hazard Statements

H315-H319-H335

Precautionary Statements

P261-P305 + P351 + P338

Required PPE

Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

WGK Germany

3

Frequently Asked Questions