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4-Pyrazoleboronic acid pinacol ester

4-Pyrazoleboronic acid pinacol ester chemical structure
CAS Number269410-08-4
FormulaN/A
Mol. Weight194.04 g/mol

What is 4-Pyrazoleboronic acid pinacol ester?

4-Pyrazoleboronic acid pinacol ester is a chemical compound with CAS number 269410-08-4. It is used in various industrial and research applications.

Applications

Reagent used for
• Suzuki-Miyaura cross-couplings1
• Ruthenium-catalyzed asymmetric hydrogenation2

Reagent used in preparation of inhibitors of many highly significant therapeutic enzymes and kinases containing the privileged scaffold pyrazole, including
• VEGF3
• Aurora3,4
• Rho (ROCK)2
• Janus Kinase 2 (JAK)5
• c-MET6
• ALK6
• S-nitrosoglutathione reductase7
• CDC78
• Acetyl-CoA carboxylase9
• Prosurvival Bcl-2 protein10
• Viral RNA-Dependent RNA polymerase11
• Long Chain Fatty Acid Elongase 612
• PI313
• AKT14
• Chk115
• 

Specifications

Linear Formula

(CH3)4C2O2BC3N2H3

Molecular Weight

194.04 g/mol

Assay/Purity

97%

Safety Information

GHS07GHS07
Signal Word

Warning

Hazard Statements

H315-H319-H335

Precautionary Statements

P261-P305 + P351 + P338

Required PPE

dust mask type N95 (US), Eyeshields, Gloves

Melting Point

142-146 °C(lit.)

WGK Germany

3

Frequently Asked Questions