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Triethyl 2-phosphonobutyrate

Triethyl 2-phosphonobutyrate chemical structure
CAS Number17145-91-4
FormulaN/A
Mol. Weight252.24 g/mol

What is Triethyl 2-phosphonobutyrate?

Triethyl 2-phosphonobutyrate is a chemical compound with CAS number 17145-91-4. It is used in various industrial and research applications.

Applications

Reactant for preparation of:
• Furospinosulin-1 and analogs as hypoxia-selective antitumor agents1
• Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs2
• Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents3
• PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists4
• Notch-sparing γ-secretase inhibitors derived from PPAR agonist library5
• Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis6
• Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimi

Specifications

Linear Formula

(C2H5O)2P(O)CH(C2H5)CO2C2H5

Molecular Weight

252.24 g/mol

Assay/Purity

98%

Boiling Point

152-154 °C/14 mmHg(lit.)

Density

1.064 g/mL at 25 °C(lit.)

Safety Information

GHS07GHS07
Signal Word

Warning

Hazard Statements

H315-H319-H335

Precautionary Statements

P261-P305 + P351 + P338

Required PPE

Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

WGK Germany

3

Frequently Asked Questions