Applications

•  Non-explosive replacement for HOBt and HOAt with at least comparable performance to HOAt
•  Outperforms HOAt in sterically demanding peptide bond formations
•  Compatible with carbodiimide-mediated; solution and solid phase peptide coupling;
•  Less epimerization than HOBt in fragment condensation reactions
•  K-salt especially useful in peptide coupling on mild acid-labile resins such as 2-chlorotrityl; leading to minimal to no cleavage of the peptide from the resin due to its more alkaline character
•  K-salt has a higher melting point than OxymaPure