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3-(Trifluoroacetyl)indole

3-(Trifluoroacetyl)indole chemical structure
CAS Number14618-45-2
FormulaC10H6F3NO
Mol. Weight213.16 g/mol

What is 3-(Trifluoroacetyl)indole?

3-(Trifluoroacetyl)indole is a chemical compound with CAS number 14618-45-2 and molecular formula C10H6F3NO. It is used in various industrial and research applications.

Applications

• Reactant for enantioselective synthesis of indoles via palladium-catalyzed kinetic asymmetrical alkylation1
• Reactant for preparation of N-pyridinyl indolecarboxamides via amidation of aminopyridine derivatives. with indolecarboxylic acid2
• Reactant for preparation of mast cell tryptase inhibitors, starting from indoles; using amidation as the key step3
• Reactant for formation of Michael adducts via Baylis-Hillman reaction4
• Reactant for preparation of indolecarboxamides via haloform cleavage of (trifluoroacetyl)indole with lithium dialkylamides5

Specifications

Molecular Weight

213.16 g/mol

Assay/Purity

99%

Safety Information

GHS07GHS07
Signal Word

Warning

Hazard Statements

H315-H319-H335

Precautionary Statements

P261-P305 + P351 + P338

Required PPE

dust mask type N95 (US), Eyeshields, Gloves

Melting Point

211-214 °C(lit.)

WGK Germany

3

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