Applications

Ethyl 2-chloro-2-(hydroxyimino)acetate has been used:
• in the preparation of (+)-and (−)-Δ²-isoxazolines¹
• in the synthesis of CIP-AS (−), a chiral amino acid structurally related to glutamic acid, potential agonist at the ionotropic (±±)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-kainate receptors²
• to generate ethoxycarbonylformonitrile oxide, in situ by treatment with sodium bicarbonate³
• to prepare N-azirdinyloximes which on treatment with scandium triflate (418218) provide dihydro-oxadiazines⁴