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mono-Ethyl malonate

mono-Ethyl malonate chemical structure
CAS Number1071-46-1
FormulaHO2CCH2CO2C2H5
Mol. Weight132.11 g/mol

What is mono-Ethyl malonate?

mono-Ethyl malonate is a chemical compound with CAS number 1071-46-1 and molecular formula HO2CCH2CO2C2H5. It is used in various industrial and research applications.

Applications

Reactant for:
• Preparation of tetramic acids via Dieckmann ring closure1
• Organocatalytic decarboxylative Doebner-Knoevenagel reactions2
• Conjugation to amino-modified oligonucleotides3
• Acylation reactions (acylation agent)4
• Indole glyoxylamides for potential Prion disease treatment5
• Knoevenagel condensation with aldehydes6

Specifications

Linear Formula

HO2CCH2CO2C2H5

Molecular Weight

132.11 g/mol

Impurities

<10% ethyl malonate, potassium salt

Boiling Point

106.5 °C/3 mmHg(lit.)

Density

1.119 g/mL at 25 °C(lit.)

Safety Information

GHS07GHS07
Signal Word

Warning

Hazard Statements

H315-H319-H335

Precautionary Statements

P261-P305 + P351 + P338

Required PPE

Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

EC Number

213-992-7

WGK Germany

3

Frequently Asked Questions