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Diethyl (2-cyanoethyl)phosphonate

Diethyl (2-cyanoethyl)phosphonate chemical structure
CAS Number10123-62-3
FormulaNC(CH2)2P(O)(OC2H5)2
Mol. Weight191.16 g/mol

What is Diethyl (2-cyanoethyl)phosphonate?

Diethyl (2-cyanoethyl)phosphonate is a chemical compound with CAS number 10123-62-3 and molecular formula NC(CH2)2P(O)(OC2H5)2. It is used in various industrial and research applications.

Applications

Reactant for:
• Heteroatom-directed alkyl cyanation of alkynes1
• Use as a fluorescent substrate for carbon-phosphorous lyase2
• Microwave-assisted cleavage of phosphate, phosphonate, and phorphoramide esters3
• Amination and stereoselective olefination for synthesis of HIV-1 antivirals4


Reactant for synthesis of:
• Base-catalyzed stereospecific anti-Markovnikov addition reactants5
• Lipophilic oxoamides with activity against phospholipase A26
• Triose phosphate isomerase of muscle inhibitors7

Specifications

Linear Formula

NC(CH2)2P(O)(OC2H5)2

Molecular Weight

191.16 g/mol

Assay/Purity

95%

Boiling Point

110 °C/0.1 mmHg(lit.)

Density

1.08 g/mL at 25 °C(lit.)

Safety Information

GHS07GHS07
Signal Word

Warning

Hazard Statements

H315-H319-H335

Precautionary Statements

P261-P305 + P351 + P338

Required PPE

Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

EC Number

233-327-4

WGK Germany

3

Frequently Asked Questions