Zileuton
Zileuton (CAS: 111406-87-2), with the molecular formula C11H12N2O2S and a molecular weight of 236.29 g/mol, is a lipoxygenase inhibitor. This white to off-white powder is primarily recognised for its role in research related to the arachidonic acid cascade and cell signalling. It serves as a valuable tool in understanding inflammatory pathways and potential therapeutic targets in conditions involving leukotriene synthesis.
- IUPAC
- (±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea
Lipoxygenase Inhibition Research
Zileuton functions as a specific inhibitor of 5-lipoxygenase, the enzyme responsible for synthesising leukotrienes. This makes it a key compound for investigating the role of leukotrienes in inflammatory and immune responses, particularly in cellular and biochemical studies.
Cellular Signalling Studies
As a modulator of the arachidonic acid cascade, Zileuton is utilised in research focused on cell signalling pathways. Its application helps elucidate the intricate mechanisms by which lipid mediators influence cellular functions and disease progression.
Drug Discovery and Development
Zileuton's established therapeutic profile as a leukotriene synthesis inhibitor makes it a reference compound in drug discovery programmes. Researchers use it to explore novel therapeutic strategies for inflammatory diseases and related conditions.
| Molecular weight | 236.29 |
|---|---|
| Empirical formula | C11H12N2O2S |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | DMSO: ≥20 mg/mL at ~60 °C (warm up to 60 C for 5min) |
| Storage temperature | room temp |
Hazard statements
- H302Harmful if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Water hazard class (WGK, DE) | 1 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Zileuton used for?
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Zileuton is used in research as a lipoxygenase inhibitor to study the arachidonic acid cascade, cell signalling, and inflammatory pathways. It is recognised as an approved therapeutic/drug candidate.
What are the CAS number and formula for Zileuton?
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The CAS number for Zileuton is 111406-87-2, and its empirical formula is C11H12N2O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Zileuton with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Zileuton be handled safely?
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Zileuton is classified as harmful if swallowed and causes serious eye irritation (H302, H319). Handle with appropriate personal protective equipment, avoid ingestion, and ensure eye protection. In case of contact, follow P305 + P351 + P338.
Is Zileuton a controlled substance?
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The provided data does not indicate that Zileuton is a controlled substance.
How is Zileuton shipped and exported?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals and laboratory reagents. Zileuton is typically shipped at room temperature. Specific export documentation and procedures will be handled according to international regulations and customer requirements.
How can I request a sample or quote for Zileuton?
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To request a sample or a quote for Zileuton, please contact our sales department through the website or by phone, providing your specific requirements and shipping details.
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