UCN-01

CAS 112953-11-4C28H26N4O4Cell Biology

UCN-01 (CAS: 112953-11-4), with the molecular formula C28H26N4O4 and a molecular weight of 482.53 g/mol, is a bioactive small molecule. It is commonly employed in biological research to investigate cellular processes, particularly in the areas of cell signalling, neuroscience, and kinase biology. Its specific use in studying checkpoint kinase-1 (CHK1) protein function and UV-induced phosphorylation makes it a valuable reagent for researchers in these fields.

IUPAC: KW-2401

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UCN-01 (C28H26N4O4) — chemical structure, CAS 112953-11-4; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyKinase/Phosphatase BiologyProtein Kinase C (PKC)U More...

01 /Applications

Checkpoint Kinase-1 (CHK1) Research

UCN-01 is utilised in studies focused on the function of checkpoint kinase-1 (CHK1) proteins. For example, it has been applied in research concerning trophoblast stem (TS) cells to elucidate CHK1's role in cellular regulation.

UV-Induced Phosphorylation Studies

This compound has been used as a research tool to examine UV-induced CHK1 phosphorylation. Experiments in IB10 cells have employed UCN-01 to investigate this specific cellular response to DNA damage.

Cell Signalling and Kinase Biology

As a bioactive small molecule, UCN-01 is relevant in broader research into cell signalling pathways and kinase biology. Its inhibitory properties are of interest to scientists studying Protein Kinase C (PKC) and serine/threonine kinase pathways.

02 /Properties

Molecular weight	482.53
Empirical formula	C28H26N4O4
Assay	≥97% (HPLC)
Form	powder
Colour	light yellow
Solubility	DMSO: >5 mg/mLH2O: insoluble
Storage temperature	2-8°C
Application	UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells1. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells2.

03 /Identifiers & registry

CAS number

112953-11-4

04 /Additional specifications

Storage Condition	protect from light

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is UCN-01 used for?

UCN-01 is primarily used in biological research to study checkpoint kinase-1 (CHK1) protein function and UV-induced CHK1 phosphorylation, as well as for broader research into cell signalling, neuroscience, and kinase biology.

What are the CAS number and formula for UCN-01?

The CAS number for UCN-01 is 112953-11-4, and its empirical formula is C28H26N4O4.

What grade and purity does Tech Serve Solutions supply for UCN-01?

Tech Serve Solutions supplies UCN-01 with a purity of ≥97% (HPLC). We do not represent this product as USP, BP, or EP grade.

What are the safety and handling precautions for UCN-01?

UCN-01 is classified with Water Hazard Class 3 (WGK 3) in Germany, indicating it is hazardous to aquatic life with long-lasting effects. Store at 2-8°C, protected from light, and handle with appropriate personal protective equipment.

How is UCN-01 packed, shipped, and exported by TSS?

UCN-01 is carefully packed to ensure product integrity during transit. As a global supplier, Tech Serve Solutions professionally exports chemicals worldwide, adhering to all relevant shipping regulations.