TPCA-1

CAS 507475-17-4C12H10FN3O2SCell Biology

TPCA-1 (CAS: 507475-17-4) is a small molecule with the chemical formula C12H10FN3O2S and a molecular weight of 279.29 g/mol. This off-white powder is primarily utilised in biological research to investigate its cytotoxic effects and its role in cellular pathways, particularly related to I Kappa B Kinase (IKK). TPCA-1 serves as a valuable tool for studies in cell biology and neuroscience, aiding researchers in understanding complex signalling mechanisms.

IUPAC: [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide

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TPCA-1 (C12H10FN3O2S) — chemical structure, CAS 507475-17-4; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyGlaxoSmithKlineI Kappa B Kinase (IKK)Kinase/Phosphatase BiologyT More...

01 /Applications

Cytotoxicity Studies

TPCA-1 has been employed in research to evaluate its cytotoxic effects on specific cell lines, such as RPMI8226 and LP1. These studies contribute to understanding the compound's potential biological activity.

Cellular Signaling Research

As an inhibitor related to I Kappa B Kinase (IKK), TPCA-1 is used to probe cellular signalling pathways. It aids in elucidating the mechanisms of serine/threonine kinase biology within cells.

Nuclear Protein Fraction Supplementation

The compound has been utilised as a supplement in cell culture media for the extraction of nuclear protein fractions from human airway smooth muscle cells, supporting biochemical analyses.

02 /Properties

Molecular weight	279.29
Empirical formula	C12H10FN3O2S
Assay	≥95% (HPLC)
Form	powder
Colour	off-white
Solubility	DMSO: ≥10 mg/mLH2O: insoluble
Storage temperature	2-8°C
Application	TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines1. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells2.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H319Causes serious eye irritation

Precautionary statements

P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-36
Safety statements (S)	26

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

507475-17-4

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is TPCA-1 used for?

TPCA-1 is used in biological research to study its cytotoxic effects and its role in cellular signalling pathways, particularly those involving I Kappa B Kinase (IKK).

What is the CAS number and chemical formula for TPCA-1?

The CAS number for TPCA-1 is 507475-17-4 and its chemical formula is C12H10FN3O2S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies TPCA-1 with a purity of $\ge$95% (HPLC). This product is intended for research purposes and is not represented as USP, BP, or EP grade.

How should TPCA-1 be handled safely?

TPCA-1 is classified as harmful if swallowed and causes serious eye irritation (H302, H319). When handling, use a dust mask type N95 (US), wear eyeshields, and gloves. Ensure proper ventilation and avoid dust formation. In case of contact with eyes, rinse cautiously with water for several minutes (P305 + P351 + P338).