O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate (CAS: 330641-16-2) is a key coupling reagent with the molecular formula C11H15BClF4N5O. Utilised extensively in chemical synthesis, particularly in peptide chemistry, it facilitates efficient amide bond formation. This compound is a valuable tool for researchers in chemical biology and organic synthesis, enabling complex molecule construction with reduced racemisation.
- IUPAC
- 1-[Bis(dimethylamino)methylen]-5-chlorobenzotriazolium 3-oxide tetrafluoroborate,N,N,N′,N′-Tetramethyl-O-(6-chloro-1H-benzotriazol-1-yl)uronium tetrafluoroborate,TCTU
- Synonyms
- N′-tetramethyluronium tetrafluoroborate,330641-16-2,C11H15BClF4N5O,1-[Bis(dimethylamino)methylen]-5-chlorobenzotriazolium 3-oxide tetrafluoroborate,N,N,N′,N′-Tetramethyl-O-(6-chloro-1H-benzotriazol-1-yl)uronium tetrafluoroborate,TCTU
Peptide Synthesis
Serves as a coupling reagent in solid-phase peptide synthesis, ensuring efficient amide bond formation with minimal racemisation. It is employed in synthesising cyclic peptide analogues and in automated synthesis platforms.
Chemical Synthesis
This uronium salt is a versatile reagent for general amide bond formation in complex organic synthesis. Its efficacy aids in the construction of diverse chemical structures.
Chemical Biology Research
Facilitates the synthesis of peptides and peptidomimetics for applications in chemical biology, enabling the study of biological processes and the development of new therapeutic agents.
| Molecular weight | 355.53 |
|---|---|
| Empirical formula | C11H15BClF4N5O |
| Assay | ≥97.5% (HPLC)98% |
| Impurities tested | ≤0.5% water |
| Application | Coupling reagent for: • Synthesis via plate-based multiple parallel centrifugation synthesizer1 • Solid-phase synthesis of cyclic gramicidin analogs2• Comparison of automatic multiple peptide synthesizers3• Solid-phase peptide coupling with lack of racemization4 |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is O-(6-Chlorobenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate used for?
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This compound is primarily used as a coupling reagent in peptide synthesis and general amide bond formation, facilitating efficient and clean reactions with minimal racemisation.
What is the CAS number and chemical formula?
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The CAS number is 330641-16-2, and the empirical formula is C11H15BClF4N5O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of ≥97.5% (HPLC) and ≤0.5% water. It is supplied as a technical/research grade and TSS does not represent it as USP/BP/EP.
What are the safety and handling precautions for this chemical?
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This chemical is classified under WGK 3 (Germany). Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or P1 (EN143) respirator filter, should be used during handling.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all relevant shipping and export regulations.
How can I request a quote or sample?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through our website or by phone.
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