N-Boc-1H-pyrazole-4-boronic acid
N-Boc-1H-pyrazole-4-boronic acid (CAS 947533-31-5), with the molecular formula C8H13BN2O4 and a molecular weight of 212.01 g/mol, is a vital organoboron compound. This protected boronic acid derivative is primarily employed as a building block in organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling for the formation of carbon-carbon bonds. Its pyrazole core and protected boronic acid functionality make it valuable for constructing complex molecules in pharmaceutical and materials science research.
- IUPAC
- 1-tert-Butoxycarbonyl-1H-pyrazole-4-boronic acid
Suzuki-Miyaura Coupling Reagent
N-Boc-1H-pyrazole-4-boronic acid serves as a key coupling partner in Suzuki-Miyaura reactions. It facilitates the formation of C-C bonds by reacting with aryl or vinyl halides and pseudohalides, enabling the synthesis of substituted pyrazoles.
Pharmaceutical Intermediate Synthesis
The compound is used in the synthesis of novel pharmaceutical agents. Its pyrazole scaffold is a common motif in many biologically active molecules, and this boronic acid derivative offers a convenient route to introduce this structure.
Materials Science Research
In materials science, this reagent can be utilised for the development of new organic electronic materials or functional polymers where a pyrazole unit is incorporated into the molecular structure.
Heterocyclic Chemistry
As a functionalised heterocycle, it is an important intermediate for academic and industrial research laboratories exploring new synthetic methodologies and the creation of novel heterocyclic compounds.
| Molecular weight | 212.01 |
|---|---|
| Empirical formula | C8H13BN2O4 |
| Assay | ≥95% |
| Storage temperature | 2-8°C |
| Melting point | 157-161 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-Boc-1H-pyrazole-4-boronic acid used for?
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N-Boc-1H-pyrazole-4-boronic acid is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds and the synthesis of complex heterocyclic compounds for pharmaceutical and materials science research.
What are the CAS number and formula for N-Boc-1H-pyrazole-4-boronic acid?
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The CAS number is 947533-31-5 and the empirical formula is C8H13BN2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-Boc-1H-pyrazole-4-boronic acid with an assay of ≥95%. We do not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should N-Boc-1H-pyrazole-4-boronic acid be handled?
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N-Boc-1H-pyrazole-4-boronic acid is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment in a well-ventilated area. Avoid breathing dust. In case of eye contact, rinse cautiously with water for several minutes, removing contact lenses if present and easy to do. Continue rinsing.
How is N-Boc-1H-pyrazole-4-boronic acid packed and exported?
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This chemical is stored at 2-8°C. Tech Serve Solutions, as a global supplier, exports chemicals internationally, adhering to all relevant shipping and customs regulations.
How can I request a sample or quote for N-Boc-1H-pyrazole-4-boronic acid?
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To request a sample or a quote, please visit the Tech Serve Solutions website and use the contact form or product inquiry function, providing the product name and CAS number.
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