N-4-Methanesulfonamidephenylboronic acid
N-4-Methanesulfonamidephenylboronic acid (CAS: 380430-57-9; Formula: C7H10BNO4S; MW: 215.03) is a boronic acid derivative offered by Tech Serve Solutions. This compound serves as a key reactant in organic synthesis, particularly for creating potent and selective inhibitors targeting IKK-β, osteoporosis treatments, and human farnesyl pyrophosphate synthase. It is also utilised in Suzuki-type palladium-catalysed coupling reactions for the synthesis of 2-arylpurines.
- IUPAC
- 4-(Dihydroxyboryl)-N-(methylsulfonyl)phenylamine,4-(Methanesulfonylamino)phenylboronic acid,4-Methylsulfonylaminophenylboronic acid,[4-[(Methanesulfonyl)amino]phenyl]boronic acid
- Synonyms
- 4-(Dihydroxyboryl)-N-(methylsulfonyl)phenylamine4-(Methanesulfonylamino)phenylboronic acid4-Methylsulfonylaminophenylboronic acid[4-[(Methanesulfonyl)amino]phenyl]boronic acid
Synthesis of IKK-β Inhibitors
Utilised as a crucial building block in the synthesis of potent and selective inhibitors of IKK-β, a target for various therapeutic applications.
Osteoporosis Treatment Development
Serves as a reactant in the preparation of inhibitors investigated for the treatment of osteoporosis.
Inhibitors of Farnesyl Pyrophosphate Synthase
Employed in the synthesis of compounds designed to inhibit human farnesyl pyrophosphate synthase.
Suzuki-Type Coupling Reactions
Acts as a reactant in Suzuki-type palladium(0) coupling reactions for the synthesis of 2-arylpurines, which are explored as Cdk inhibitors.
| Molecular weight | 215.03 |
|---|---|
| Empirical formula | C7H10BNO4S |
| Assay | ≥95% |
| Application | Reactant for preparation of:• Potent and selective inhibitors of IKK-β1• Inhibitors for treatment of osteoporosis2• Inhibitors of human farnesyl pyrophosphate synthase3• Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors4 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 1 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N-4-Methanesulfonamidephenylboronic acid used for?
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N-4-Methanesulfonamidephenylboronic acid is primarily used as a reactant in organic synthesis for the preparation of various inhibitors, including those targeting IKK-β, osteoporosis, and farnesyl pyrophosphate synthase, as well as in Suzuki-type coupling reactions for 2-arylpurine synthesis.
What is the CAS number and formula for N-4-Methanesulfonamidephenylboronic acid?
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The CAS number is 380430-57-9 and the empirical formula is C7H10BNO4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N-4-Methanesulfonamidephenylboronic acid with a purity of ≥95%. This product is intended for research and technical use and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions for this chemical?
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This compound carries a Warning signal word and is classified with hazards H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including gloves, eye protection, and ensure adequate ventilation. Avoid breathing dust.
How is N-4-Methanesulfonamidephenylboronic acid packed and shipped?
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Tech Serve Solutions, as a specialist global supplier and exporter of fine chemicals, ensures appropriate packaging and adherence to all relevant shipping regulations for international export.
How can I request a sample or quote for N-4-Methanesulfonamidephenylboronic acid?
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Please contact our sales team via the website or direct email to request a sample or a quotation. Please specify the quantity required and your shipping destination.
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