Methyl (S)-(+)-mandelate
Methyl (S)-(+)-mandelate (CAS: 21210-43-5), with the molecular formula C6H5CH(OH)CO2CH3 and a molecular weight of 166.17 g/mol, is a chiral ester widely utilised in asymmetric synthesis. Its specific optical activity and high optical purity make it a valuable building block in organic synthesis for creating enantiomerically pure compounds. It is commonly employed in the chemical and pharmaceutical industries for the development of complex molecules.
- IUPAC
- (+)-Methyl (S)-α-hydroxyphenylacetate,(+)-Methyl L-mandelate
Chiral Building Block in Organic Synthesis
Methyl (S)-(+)-mandelate serves as a key chiral synthon for introducing stereochemical complexity into target molecules. Its well-defined stereochemistry is crucial for the synthesis of enantiopure pharmaceuticals and fine chemicals.
Asymmetric Synthesis
This compound is instrumental in asymmetric synthesis methodologies, enabling the stereoselective formation of new chiral centres. It is often used as a precursor or auxiliary in reactions requiring high enantioselectivity.
Chiral Resolution
As a chiral resolving agent or precursor to resolving agents, Methyl (S)-(+)-mandelate aids in the separation of racemic mixtures into their constituent enantiomers. This is vital for obtaining single-enantiomer active pharmaceutical ingredients.
| Molecular weight | 166.17 |
|---|---|
| Linear formula | C6H5CH(OH)CO2CH3 |
| Assay | ≥99% |
| Optical activity | [α]20/D +144°, c = 1 in methanol |
| Optical purity | ee: 98% (HPLC) |
| Melting point | 56-58 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl (S)-(+)-mandelate primarily used for?
+
Methyl (S)-(+)-mandelate is primarily used as a chiral building block in asymmetric synthesis and for chiral resolution in the development of enantiomerically pure compounds, particularly within the pharmaceutical and fine chemical industries.
What are the CAS number and molecular formula for Methyl (S)-(+)-mandelate?
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The CAS number for Methyl (S)-(+)-mandelate is 21210-43-5, and its molecular formula is C6H5CH(OH)CO2CH3.
What grade and purity does Tech Serve Solutions supply for Methyl (S)-(+)-mandelate?
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Tech Serve Solutions supplies Methyl (S)-(+)-mandelate with an assay of ≥99% and an optical purity of ee: 98% (HPLC). We do not represent this product as USP, BP, or EP grade unless explicitly stated.
What are the safety and handling requirements for Methyl (S)-(+)-mandelate?
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Handling Methyl (S)-(+)-mandelate requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It has a WGK Germany rating of 3, indicating it is hazardous to water.
How is Methyl (S)-(+)-mandelate typically packed and shipped by TSS?
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Tech Serve Solutions exports fine chemicals globally, adhering to all necessary regulations for safe and secure packaging and shipment of laboratory reagents and intermediates.
How can I request a sample or a quote for Methyl (S)-(+)-mandelate?
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To request a sample or a quote for Methyl (S)-(+)-mandelate, please contact our sales department via the website or by phone, providing your specific requirements.
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