Ibotenic acid
Ibotenic acid (CAS 2552-55-8; C5H6N2O4; MW: 158.11) is a white solid compound. As a potent neuroactive excitotoxin, it acts as a non-selective agonist for glutamate receptors, particularly targeting NMDA and AMPA receptor subtypes. It is widely utilised in neuroscience research to induce localised excitotoxicity, enabling the study of neuronal cell death pathways and the effects of neurodegeneration in animal models. Its applications are primarily within biochemical and neurological research settings.
- IUPAC
- α-Amino-3-hydroxy-5-isoxazoleacetic acid
Neuroscience Research Tool
Ibotenic acid is extensively used in experimental neuroscience to selectively lesion specific brain regions. By inducing excitotoxicity, it allows researchers to model neurodegenerative diseases and study neuronal damage.
Excitatory Amino Acid Agonist
This compound serves as a potent agonist for ionotropic glutamate receptors, including NMDA and AMPA receptors. It is valuable for investigating receptor function and the downstream signaling pathways in the central nervous system.
Cellular Studies
It is employed in cell biology to study cellular responses to excitotoxic stress and to explore mechanisms of neuroprotection against glutamate-induced damage.
| Molecular weight | 158.11 |
|---|---|
| Empirical formula | C5H6N2O4 |
| Assay | ~95% |
| Form | solid |
| Colour | white |
| Solubility | H2O: soluble1 mg/mL, clear, colorless (with sonication)0.1 M NaOH: soluble10.7 mg/mL0.1 M HCl: soluble4.7 mg/mL |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25 |
| Safety statements (S) | 22-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | rat ... Grm1(24414), Grm2(24415) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is ibotenic acid used for?
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Ibotenic acid is primarily used in neuroscience research as a tool to induce excitotoxicity, enabling the study of neuronal cell death pathways and neurodegenerative processes in experimental models. It also serves as an agonist for excitatory amino acid receptors.
What are the CAS number and chemical formula for ibotenic acid?
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The CAS number for ibotenic acid is 2552-55-8, and its chemical formula is C5H6N2O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies ibotenic acid with a purity of approximately 95% (Assay: ~95%). This product is intended for research purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should ibotenic acid be handled safely?
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Ibotenic acid is classified as acutely toxic if swallowed (H301) and requires stringent safety precautions. Handling should be performed in a well-ventilated area or fume hood, using appropriate personal protective equipment including eyeshields, face shields, gloves, and a P2 respirator cartridge. Emergency procedures should be readily available.
Can Tech Serve Solutions export ibotenic acid?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including ibotenic acid, adhering to all relevant international shipping regulations for hazardous materials.
How can I request a quote or sample for ibotenic acid?
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To request a quote or a sample of ibotenic acid, please contact our sales department via the website or provide your details through the product inquiry form.
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