Fmoc-4-(phosphonomethyl)-Phe-OH
Fmoc-4-(phosphonomethyl)-Phe-OH (CAS: 229180-64-7), a derivative of phenylalanine with the empirical formula C25H24NO7P and a molecular weight of 481.43, is a key reagent in peptide synthesis. This unnatural amino acid derivative is invaluable for introducing phosphonomethyl groups into peptides, enabling the study of phosphoprotein analogues and modified biological systems. Its primary utility lies in advanced chemical synthesis and chemical biology research.
- IUPAC
- Fmoc-4-(phosphonomethyl)-L-phenylalanine
- Synonyms
- Fmoc-4-(phosphonomethyl)-L-phenylalanine

Peptide Synthesis
Incorporates unnatural phosphonomethyl functionality into peptide chains. Facilitates the creation of peptide analogues for biochemical research and drug discovery.
Chemical Biology
Enables the synthesis of phosphoprotein mimetics and modified peptides for investigating biological pathways. Useful for studying enzyme mechanisms and protein-ligand interactions.
Chemical Synthesis
Serves as a building block for complex organic molecules containing modified amino acid structures. Useful in the development of novel chemical entities.
| Molecular weight | 481.43 |
|---|---|
| Empirical formula | C25H24NO7P |
| Assay | ≥98.0% (TLC) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Fmoc-4-(phosphonomethyl)-Phe-OH used for?
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Fmoc-4-(phosphonomethyl)-Phe-OH is used in peptide synthesis, chemical biology, and general chemical synthesis for introducing phosphonomethyl groups into peptide chains and for creating unnatural amino acid derivatives.
What is the CAS number and formula for Fmoc-4-(phosphonomethyl)-Phe-OH?
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The CAS number is 229180-64-7, and the empirical formula is C25H24NO7P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Fmoc-4-(phosphonomethyl)-Phe-OH with an assay of ≥98.0% (TLC). This product is not supplied as USP, BP, EP, or pharmacopoeia grade.
How should Fmoc-4-(phosphonomethyl)-Phe-OH be handled?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter. This compound carries a WGK Germany rating of 3.
How is Fmoc-4-(phosphonomethyl)-Phe-OH shipped?
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This chemical is typically stored at 2-8°C and shipped under appropriate temperature-controlled conditions suitable for fine chemicals.
How can I request a sample or quote for Fmoc-4-(phosphonomethyl)-Phe-OH?
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Please contact the Tech Serve Solutions sales team via our website or direct contact details to request a sample or obtain a quotation.
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