Ethyl (4-methylbenzoyl)acetate
Ethyl (4-methylbenzoyl)acetate (CAS 27835-00-3) is a valuable organic compound with the molecular formula C<sub>12</sub>H<sub>14</sub>O<sub>3</sub> and a molecular weight of 206.24 g/mol. This ester, belonging to the carbonyl compounds and organic building blocks categories, serves as a versatile reactant in various organic syntheses. Its utility spans oxidative cross-coupling, halogenation reactions, and cyclisation processes, making it a key intermediate for developing complex molecules.
- IUPAC
- Ethyl 3-(4-methylphenyl)-3-oxopropanoate,Ethyl 3-oxo-3-(4-tolyl)propionate,NSC 158544
- Synonyms
- Ethyl 3-(4-methylphenyl)-3-oxopropanoateEthyl 3-oxo-3-(4-tolyl)propionateNSC 158544
Organic Synthesis Intermediate
Ethyl (4-methylbenzoyl)acetate is employed as a reactant in diverse organic transformations. It participates in key reactions such as oxidative cross-coupling with indoles and electrophilic or nucleophilic halogenation.
Heterocyclic Chemistry
This compound facilitates the synthesis of heterocyclic frameworks. It can undergo cyclisation reactions with alkynyl ketones, contributing to the construction of complex ring systems.
Catalysis and Reduction Reactions
Its reactivity extends to Lewis base-catalyzed hydrosilylation and stereoselective reduction processes. These applications highlight its importance in controlled chemical transformations.
Michael Addition Reactions
Ethyl (4-methylbenzoyl)acetate is a substrate in intramolecular Michael addition reactions. This enables the formation of new carbon-carbon bonds, crucial for synthetic strategies.
| Molecular weight | 206.24 |
|---|---|
| Linear formula | CH3C6H4COCH2CO2CH2CH3 |
| Boiling point | 244-245 °C(lit.) |
| Density | 1.056 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5315(lit.) |
| Application | Reactant involved in:• Oxidative cross-coupling with indoles1• Electrophilic / nucleophilic halogenation2• Cyclization with alkynyl ketones3• Lewis base catalyzed hydrosilylation4• Stereoselective reduction5• Intramolecular Michael addition reactions6 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ethyl (4-methylbenzoyl)acetate used for?
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Ethyl (4-methylbenzoyl)acetate is used as a reactant in various organic syntheses, including oxidative cross-coupling, halogenation, cyclisation with alkynyl ketones, Lewis base-catalyzed hydrosilylation, stereoselective reduction, and intramolecular Michael addition reactions.
What is the CAS number and molecular formula for Ethyl (4-methylbenzoyl)acetate?
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The CAS number is 27835-00-3, and the linear molecular formula is CH<sub>3</sub>C<sub>6</sub>H<sub>4</sub>COCH<sub>2</sub>CO<sub>2</sub>CH<sub>2</sub>CH<sub>3</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ethyl (4-methylbenzoyl)acetate with a typical purity of 98% or higher, often indicated by a refractive index of n20/D 1.5315(lit.). This product is supplied for research and development purposes and is not represented as USP/BP/EP grade.
What are the safety and handling precautions for Ethyl (4-methylbenzoyl)acetate?
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Handling Ethyl (4-methylbenzoyl)acetate requires appropriate personal protective equipment, including eyeshields and gloves. It is classified under WGK 2 in Germany, indicating it is hazardous to water. Always consult the Safety Data Sheet (SDS) before use.
How is Ethyl (4-methylbenzoyl)acetate packed and exported?
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Tech Serve Solutions packs and exports chemicals professionally to meet international standards, ensuring safe transit and compliance with all necessary regulations for global distribution.
How can I request a quote or sample for Ethyl (4-methylbenzoyl)acetate?
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To request a quote or a sample of Ethyl (4-methylbenzoyl)acetate, please contact our sales team through the website or by phone, providing your specific requirements and shipping details.
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