Ara-G hydrate
Ara-G hydrate (CAS 38819-10-2) is a chemical compound with the formula C10H13N5O5 · xH2O and a molecular weight of 283.24 (anhydrous basis). This antineoplastic and antimetabolite agent functions as an apoptosis inducer by being converted to its active triphosphate form, inhibiting DNA synthesis. It is available as a solid with an assay of ≥98% (HPLC), supplied by Tech Serve Solutions for research applications.
- IUPAC
- 9-β-D-Arabinofuranosyl guanine hydrate
- Synonyms
- 9-β-D-Arabinofuranosyl guanine hydrate
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Apoptosis Induction
Ara-G hydrate is metabolised by cellular kinases to its active triphosphate form, Ara-GTP. This active metabolite is known to induce apoptosis in various cell types, making it a valuable tool for studying programmed cell death.
Inhibition of DNA Synthesis
As an antimetabolite, Ara-G hydrate interferes with cellular processes. Its active form, Ara-GTP, inhibits DNA synthesis, contributing to its antineoplastic properties and utility in cancer research.
Antineoplastic Research
With its ability to induce apoptosis and inhibit DNA synthesis, Ara-G hydrate serves as a significant compound in antineoplastic research, investigating potential therapeutic strategies against cancer.
| Molecular weight | 283.24 (anhydrous basis) |
|---|---|
| Empirical formula | C10H13N5O5 · xH2O |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | DMSO: >10 mg/mLH2O: insoluble |
| Storage temperature | 2-8°C |
| Application | Ara-G is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. This active form of Ara-G induces apoptosis and inhibits DNA synthesis. Ara-G is also an antineoplastic and antimetabolite. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Ara-G hydrate used for?
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Ara-G hydrate is used for inducing apoptosis and inhibiting DNA synthesis. It functions as an antineoplastic and antimetabolite agent, primarily for research purposes.
What are the CAS number and formula for Ara-G hydrate?
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The CAS number for the anhydrous form is 38819-10-2. The empirical formula is C10H13N5O5 · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Ara-G hydrate with an assay of ≥98% (HPLC). This product is supplied for research purposes and is not represented as USP, BP, or EP grade.
How should Ara-G hydrate be handled safely?
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Ara-G hydrate is classified with GHS07 symbol and a 'Warning' signal word. It carries hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, should be used. Work in a well-ventilated area or fume hood.
How is Ara-G hydrate packed and shipped?
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Ara-G hydrate is typically supplied as a solid and stored at 2-8°C. For export, it is carefully packed to maintain its integrity during transit, adhering to international shipping regulations for chemical compounds.
How can I request a quote or sample for Ara-G hydrate?
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To request a quote or sample for Ara-G hydrate, please contact the Tech Serve Solutions sales department via the website or direct inquiry, providing your contact details and intended use.
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