5-Norbornene-2-endo-acetic acid

CAS 825-71-8C9H12O2Chemical Synthesis

5-Norbornene-2-endo-acetic acid (CAS: 825-71-8, C9H12O2) is a functionalized norbornene monomer. It features a carboxylic acid group, enabling modification of amine-containing compounds through peptide coupling. The norbornene moiety participates in inverse electron demand Diels-Alder reactions, making it valuable for bioorthogonal click chemistry, particularly in biological imaging and advanced materials science.

IUPAC: Bicyclo[2.2.1]hept-5-en-2-ylacetic acid,Norbornene acetic acid

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5-Norbornene-2-endo-acetic acid (C9H12O2) — chemical structure, CAS 825-71-8; Chemistry, fine chemical supplied by Tech Serve Solutions

AlkenesBuilding BlocksChemical BiologyChemical SynthesisAlkynes and Other ReagentsCyclicLithography MonomersMaterials ScienceMicro/NanoElectronicsMonomers

01 /Applications

Bioorthogonal Click Chemistry

Utilised in inverse electron demand Diels-Alder cycloadditions with tetrazines for bioorthogonal applications such as biological imaging and labelling.

Peptide and Protein Modification

The carboxylic acid group facilitates conjugation to amine-containing biomolecules like proteins and peptides via standard coupling techniques.

Monomer for Polymer Synthesis

Serves as a building block for specialised polymers, contributing etch-resistant properties useful in microelectronics and lithography.

Organic Synthesis Intermediate

A versatile building block for constructing complex organic molecules, leveraging both the norbornene ring system and the acetic acid functionality.

02 /Properties

Empirical formula	C9H12O2
Density	1.124 g/mL at 25 °C
Refractive index	n20/D 1.495
Application	Carboxylic acid functionalized norbornene. Carboxylic acid can be used to modify amine containing compounds such as lysine residues on proteins/peptides via standard peptide coupling methods. Norbornene has been shown to react with 1,2,4,5-tetrazines in an inverse electron demand Diels-Alder cycloaddition reaction, which is a bioorthogonal click chemistry reaction demonstrated to be useful in biological imaging applications.

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed
H412Harmful to aquatic life with long-lasting effects

Precautionary statements

P273Avoid release to the environment

Flash point	>110 °C / >230 °F
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

825-71-8

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 5-Norbornene-2-endo-acetic acid used for?

5-Norbornene-2-endo-acetic acid is used in bioorthogonal click chemistry, for modifying amine-containing compounds like proteins and peptides, and as a monomer in polymer synthesis for applications in microelectronics and lithography.

What is the CAS number and formula for 5-Norbornene-2-endo-acetic acid?

The CAS number is 825-71-8 and the empirical formula is C9H12O2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product as a research-grade chemical. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade.

How should 5-Norbornene-2-endo-acetic acid be handled safely?

Warning: Harmful if swallowed. Harmful to aquatic life with long lasting effects. Avoid release to the environment. Handle with appropriate personal protective equipment in a well-ventilated area.