4-Nitrobenzotrifluoride
4-Nitrobenzotrifluoride (CAS: 402-54-0; Formula: O2NC6H4CF3) is a trifluoromethylated nitroaromatic compound with a molecular weight of 191.11 g/mol. It serves as a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. Its unique structure, featuring both a nitro group and a trifluoromethyl group on a benzene ring, makes it a versatile building block for creating complex molecules with specific electronic and steric properties.
- IUPAC
- 4-Nitro-α,α,α-trifluorotoluene
- Synonyms
- 4-Nitro-α,α,α-trifluorotoluene
Pharmaceutical Intermediate
Used in the synthesis of active pharmaceutical ingredients (APIs). The trifluoromethyl group can enhance lipophilicity and metabolic stability of drug candidates.
Agrochemical Synthesis
Serves as a precursor for the development of new pesticides and herbicides. Its chemical structure can be modified to target specific biological pathways in pests or weeds.
Organic Building Block
A versatile reagent in general organic chemistry for introducing the 4-nitrophenyl or 4-trifluoromethylphenyl moiety into larger molecules.
Material Science Research
Investigated for potential use in the development of specialty materials due to its electronic properties conferred by the nitro and trifluoromethyl substituents.
| Molecular weight | 191.11 |
|---|---|
| Linear formula | O2NC6H4CF3 |
| Assay | 98% |
| Boiling point | 81-83 °C/10 mmHg(lit.) |
| Melting point | 38-40 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H330Fatal if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P284Wear respiratory protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 88 °C / 190.4 °F |
| Transport (UN / ADR) | UN 3431 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 22-26-36/37/38 |
| Safety statements (S) | 26-28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrobenzotrifluoride used for?
+
4-Nitrobenzotrifluoride is primarily used as an intermediate in organic synthesis, notably in the development of pharmaceuticals and agrochemicals, and as a general building block in chemical synthesis.
What is the CAS number and formula for 4-Nitrobenzotrifluoride?
+
The CAS number is 402-54-0, and the chemical formula is O2NC6H4CF3.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 4-Nitrobenzotrifluoride with a minimum assay of 98%. This product is intended for laboratory and industrial use; TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.
How should 4-Nitrobenzotrifluoride be handled safely?
+
4-Nitrobenzotrifluoride is classified as acutely toxic if inhaled and is harmful if swallowed or causes skin and eye irritation. Handle with appropriate personal protective equipment including eyeshields, gloves, and a respirator (type N100 or P3 recommended). Ensure adequate ventilation and avoid dust formation. Refer to the Safety Data Sheet for comprehensive handling information.
Is 4-Nitrobenzotrifluoride shipped internationally?
+
Yes, Tech Serve Solutions is a global supplier and exporter of chemicals, including 4-Nitrobenzotrifluoride, adhering to all relevant shipping regulations.
How can I request a quote or sample for 4-Nitrobenzotrifluoride?
+
To request a quote or sample, please contact our sales team via the website or direct email, providing your specific requirements and shipping details.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis