4-Fluoroindole
4-Fluoroindole (CAS: 387-43-9), with the molecular formula C8H6FN and a molecular weight of 135.14 g/mol, is a vital fluorinated heterocyclic building block. It serves as a key intermediate in the synthesis of various complex organic molecules. Its applications span across pharmaceutical research and development, including the creation of potential anticancer agents, antifungal compounds, and modulators of neurological pathways. This compound is essential for chemists engaged in advanced synthetic strategies.
Anticancer and Immunomodulatory Agents
4-Fluoroindole is utilised as a reactant in the preparation of novel pyridyl-ethenyl-indole derivatives. These compounds have shown potential as anticancer immunomodulators by inhibiting tryptophan dioxygenase.
Antifungal Compounds
This fluorinated indole serves as a precursor in the synthesis of various antifungal agents, contributing to the development of new treatments for fungal infections.
Diabetes Management Therapeutics
It functions as a reactant in the synthesis of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) inhibitors, which are crucial for managing hyperglycemia in patients with diabetes.
Neuroscience Research
4-Fluoroindole is employed in the synthesis of potent and selective serotonin reuptake inhibitors (SSRIs), impacting research into neurological disorders and mental health.
Antiviral Drug Development
The compound is a reactant for the preparation of molecules investigated for their ability to inhibit HIV-1 attachment, contributing to the search for new antiviral therapies.
| Molecular weight | 135.14 |
|---|---|
| Empirical formula | C8H6FN |
| Assay | 97% |
| Boiling point | 90 °C/0.4 mmHg(lit.) |
| Application | • Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators1• Reactant for preparation of antifungal agents2• Reactant for preparation of Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes3• Reactant for preparation of Potent Selective Serotonin Reuptake Inhibitors4• Reactant for preparation of Inhibitors of HIV-1 attachment5• Reactant for preparation of monoamine reuptake inhibitors6• Reactant for preparation of histone deacetylase (HDAC) inhibitors7• Reactant for preparation of inhibitors of proliferation of human breast cancer cells8 |
| Melting point | 30-32 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoroindole used for?
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4-Fluoroindole is primarily used as a building block in chemical synthesis, particularly for creating potential pharmaceutical agents such as anticancer drugs, antifungal compounds, SGLT2 inhibitors for diabetes management, selective serotonin reuptake inhibitors, and inhibitors of HIV-1 attachment.
What are the CAS number and formula for 4-Fluoroindole?
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The CAS number for 4-Fluoroindole is 387-43-9, and its empirical formula is C8H6FN.
What grade and purity does Tech Serve Solutions supply for 4-Fluoroindole?
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Tech Serve Solutions supplies 4-Fluoroindole with an assay of 97%. This is a technical/research grade material and is not represented as USP, BP, EP, or any other pharmacopoeial standard.
How should 4-Fluoroindole be handled safely?
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4-Fluoroindole is classified as a Warning substance with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves, in a well-ventilated area.
Can Tech Serve Solutions export 4-Fluoroindole?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, and can export 4-Fluoroindole to qualified customers worldwide.
How can I request a quote or sample of 4-Fluoroindole?
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To request a quote or a sample of 4-Fluoroindole, please contact our sales department through the website or by phone. Our team will be pleased to assist you with your requirements.
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