4-Bromo-α-cyanocinnamic acid
4-Bromo-α-cyanocinnamic acid (CAS 339548-64-0) is a chemical compound with a molecular weight of 252.06 g/mol. It is primarily recognised for its utility as a matrix substance in Matrix-Assisted Laser Desorption/Ionization (MALDI) mass spectrometry. This application is crucial for the ionisation of various analytes, including peptides and lipids, facilitating their detection and analysis in complex biological samples.
- IUPAC
- 3-(4-Bromophenyl)-2-cyano-2-propenoic acid,p-Bromobenzylidenecyanoacetic acid,p-Bromo-α-cyanocinnamic acid,BrCCA
- Synonyms
- p-Bromobenzylidenecyanoacetic acid3-(4-Bromophenyl)-2-cyano-2-propenoic acidp-Bromo-α-cyanocinnamic acidBrCCA
MALDI Mass Spectrometry Matrix
4-Bromo-α-cyanocinnamic acid serves as an effective matrix material for MALDI-MS analysis. It aids in the efficient desorption and ionisation of analytes, making it suitable for the characterisation of peptides, phospholipids, and other fragile molecules.
Proteomics and Lipidomics Research
Its application extends to the fields of proteomics and lipidomics, where it assists in the sensitive detection and quantification of peptides, phosphopeptides, and various classes of lipids through mass spectrometry.
Analysis of Fragile Analytes
The compound is particularly useful for the analysis of sensitive or fragile analytes, including drugs, ionic liquids, and chlorinated lipids, where gentle ionisation conditions are required for accurate mass spectral data acquisition.
| Molecular weight | 252.06 |
|---|---|
| Empirical formula | C10H6BrNO2 |
| Assay | ≥95.0% (HPLC) |
| Grade | matrix substance for MALDI-MS |
| Solubility | methanol: soluble100 mg/10 mL, clear, colorless to light yellow |
| Application | suitable as MALDI-Matrix material |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36-37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Analyte Suitability | CID-MS/MSME-SIMSchlorinated lipidsdrugsfragile analytesionic liquids (quantification)lipidspeptidesphospholipidsphosphopeptides |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-α-cyanocinnamic acid used for?
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4-Bromo-α-cyanocinnamic acid is primarily used as a matrix substance for Matrix-Assisted Laser Desorption/Ionisation (MALDI) mass spectrometry, particularly for the analysis of peptides, lipids, and other fragile analytes.
What is the CAS number and molecular formula for 4-Bromo-α-cyanocinnamic acid?
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The CAS number is 339548-64-0, and the molecular formula is C10H6BrNO2.
What grade and purity does Tech Serve Solutions supply for 4-Bromo-α-cyanocinnamic acid?
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Tech Serve Solutions supplies 4-Bromo-α-cyanocinnamic acid with an assay of ≥95.0% (HPLC) and it is designated as a matrix substance for MALDI-MS. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 4-Bromo-α-cyanocinnamic acid be handled safely?
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4-Bromo-α-cyanocinnamic acid is classified with GHS07, carries a Warning signal word, and has hazard statements including H302 + H312 + H332 (Harmful if swallowed, in contact with skin or if inhaled), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection in a well-ventilated area. Refer to the Safety Data Sheet (SDS) for comprehensive handling information.
How is 4-Bromo-α-cyanocinnamic acid packed and shipped by TSS?
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Tech Serve Solutions professionally packs and ships chemicals globally, adhering to international transport regulations to ensure safe and compliant delivery.
How can I request a quote or sample of 4-Bromo-α-cyanocinnamic acid?
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Please contact our sales team via the website or direct email to request a quotation or a product sample.
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