3-Chloro-4-fluorophenylboronic acid
3-Chloro-4-fluorophenylboronic acid (CAS: 144432-85-9) is an organoboron compound with the molecular formula ClC6H3(F)B(OH)2 and a molecular weight of 174.37 g/mol. This disubstituted aryl boronic acid serves as a valuable building block in organic synthesis. It is primarily utilised as a reactant in various catalysed reactions, including asymmetric additions, oxidative cross-couplings, and Suzuki-Miyaura couplings, facilitating the formation of complex organic molecules.
- IUPAC
- (3-Chloro-4-fluorophenyl-1-yl)boronic acid,3-Chloro-4-fluorobenzeneboronic acid,4-Fluoro-3-chlorophenylboronic acid
- Synonyms
- 4-Fluoro-3-chlorophenylboronic acid3-Chloro-4-fluorobenzeneboronic acid
Rhodium-Catalyzed Asymmetric Addition
3-Chloro-4-fluorophenylboronic acid is employed as a reactant in rhodium-catalysed asymmetric addition reactions, enabling stereoselective synthesis of chiral compounds.
Palladium-Catalyzed Oxidative Cross-Coupling
This boronic acid participates in palladium-catalysed oxidative cross-coupling reactions, a key methodology for carbon-carbon bond formation in complex molecule synthesis.
Suzuki-Miyaura Coupling Reactions
As a versatile aryl boronic acid, it is a common coupling partner in Suzuki-Miyaura reactions, widely used for the synthesis of biaryl compounds and other substituted aromatic systems.
| Molecular weight | 174.37 |
|---|---|
| Linear formula | ClC6H3(F)B(OH)2 |
| Application | Reactant for:• Rh-catalyzed asymmetric addition reactions1• Palladium-catalyzed oxidative cross-coupling reaction2• Suzuki-Miyaura coupling3 |
| Melting point | 242-247 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-4-fluorophenylboronic acid used for?
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3-Chloro-4-fluorophenylboronic acid is primarily used as a reactant in catalysed organic synthesis, including rhodium-catalysed asymmetric additions, palladium-catalysed oxidative cross-coupling reactions, and Suzuki-Miyaura couplings.
What are the CAS number and chemical formula for 3-Chloro-4-fluorophenylboronic acid?
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The CAS number is 144432-85-9, and the chemical formula is ClC6H3(F)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound as a technical or research grade chemical. We do not represent it as USP, BP, EP, or for food/pharmaceutical use unless explicitly stated in product documentation. Please refer to the specific Certificate of Analysis for lot-specific purity.
What are the safety and handling considerations for this compound?
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Appropriate personal protective equipment, including eyeshields and gloves, should be worn. A type N95 (US) or type P1 (EN143) respirator filter is recommended. This compound is classified under WGK Germany 3, indicating significant hazard to water.
How is 3-Chloro-4-fluorophenylboronic acid shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, capable of fulfilling international orders for 3-Chloro-4-fluorophenylboronic acid in compliance with relevant shipping regulations.
How can I request a sample or quote?
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To request a sample or a quotation for 3-Chloro-4-fluorophenylboronic acid, please contact our sales team through the website or by phone.
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