3-Aminocarbonylphenylboronic acid
3-Aminocarbonylphenylboronic acid (CAS 351422-73-6) is an organoboron compound with the linear formula (H2NCO)C6H4B(OH)2 and a molecular weight of 164.95 g/mol. This versatile aryl boronic acid serves as a key reactant in advanced chemical synthesis. It is primarily utilised in the creation of various inhibitors, including phosphodiesterase 10A inhibitors and STAT3 protein inhibitors, as well as in pyrimidine derivatives for TpI2 kinase inhibition.
- IUPAC
- 3-Carbamoylphenylboronic acid
- Synonyms
- 3-Carbamoylphenylboronic acid
Synthesis of PDE10A Inhibitors
3-Aminocarbonylphenylboronic acid is a crucial building block in the synthesis of orally active phosphodiesterase 10A (PDE10A) inhibitors. These compounds are of significant interest in neurological research and therapeutic development.
Development of TpI2 Kinase Inhibitors
This boronic acid is employed in the preparation of pyrimidine derivatives that act as inhibitors of TpI2 kinase. This application highlights its utility in the field of targeted cancer therapy research.
STAT3 Protein Inhibitor Synthesis
The compound serves as a reactant in the development of peptidomimetic inhibitors targeting the STAT3 protein. This is relevant for research into oncogenic signalling pathways and the development of novel anti-cancer agents.
Organometallic Coupling Reactions
3-Aminocarbonylphenylboronic acid participates in various cross-coupling reactions, including Suzuki couplings and oxidative cross-coupling with mercaptoacetylenes. It is also used in trifluoromethylation reactions.
| Molecular weight | 164.95 |
|---|---|
| Linear formula | (H2NCO)C6H4B(OH)2 |
| Storage temperature | 2-8°C |
| Application | Reactant involved in the synthesis of a variety of inhibitors including:• Orally active phosphodiesterase 10A inhibitors1• Pyrimidine derivatives as TpI2 kinase inhibitors2• Peptidomimetic inhibitors of STAT3 protein3Reactant involved in:• Oxidative cross-coupling with mercaptoacetylenes4• Trifluoromethylation via a Collidine trifluoromethylating agent5• Suzuki cross-coupling reactions6 |
| Melting point | 221-226 °C |
Hazard statements
- H302Harmful if swallowed
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Aminocarbonylphenylboronic acid used for?
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3-Aminocarbonylphenylboronic acid is used as a reactant in chemical synthesis, particularly for creating inhibitors such as phosphodiesterase 10A inhibitors, pyrimidine derivatives for TpI2 kinase inhibition, and peptidomimetic inhibitors of STAT3 protein. It also participates in oxidative cross-coupling and Suzuki cross-coupling reactions.
What is the CAS number and chemical formula for 3-Aminocarbonylphenylboronic acid?
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The CAS number is 351422-73-6, and the linear chemical formula is (H2NCO)C6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply for 3-Aminocarbonylphenylboronic acid?
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Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. The specific grade and purity available should be confirmed with our sales team. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling recommendations for 3-Aminocarbonylphenylboronic acid?
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Based on GHS information, this compound is classified with a Warning signal word and carries the hazard statement H302 (Harmful if swallowed). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area.
How is 3-Aminocarbonylphenylboronic acid packed, shipped, and exported by TSS?
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Tech Serve Solutions meticulously packages and exports chemicals globally, adhering to all relevant international shipping regulations to ensure safe and compliant delivery of your order.
How can I request a sample or a quote for 3-Aminocarbonylphenylboronic acid?
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To request a sample or a quotation, please contact our dedicated sales department through the website or by calling our office. Our team will respond promptly to your inquiry.
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