2-(Trifluoromethyl)benzaldehyde
2-(Trifluoromethyl)benzaldehyde (CAS 447-61-0), with the molecular formula CF3C6H4CHO and a molar mass of 174.12 g/mol, is a fluorinated aromatic aldehyde. This compound serves as a valuable building block in organic synthesis. Its key applications include its use in the preparation of complex organic molecules, particularly in the pharmaceutical and chemical research sectors, where it functions as a reactive intermediate for introducing the trifluoromethylphenyl moiety.
- IUPAC
- α,α,α-Trifluoro-o-tolualdehyde
- Synonyms
- α,α,α-Trifluoro-o-tolualdehyde
Preparation of Dihydropyridine Derivatives
2-(Trifluoromethyl)benzaldehyde has been employed in the synthesis of complex dihydropyridine structures. For instance, it has been used in the preparation of ω-(dimethylamino)-alkyl<wbr>ethyl-4(-2-(trifluorormet<wbr>hyl)phenyl)-2,6-dimethyl-<wbr>1,4-dihydropyridine-3,5-d<wbr>icarboxylates.
Wittig-Horner Reaction Intermediate
This aldehyde is a useful precursor in olefination reactions. It has been utilised in the Wittig-Horner reaction to prepare methyl (<i>E</i>)-2-[2-[(<i>E</i>)-2-(2-trifluoromethylphe<wbr>nyl)vinyl]-phenyl]-3-meth<wbr>oxyacrylate.
Organic Synthesis Building Block
As a functionalised benzaldehyde, 2-(trifluoromethyl)benzaldehyde is a versatile building block for constructing more complex organic molecules. Its trifluoromethyl group offers unique electronic properties for further chemical transformations.
| Molecular weight | 174.12 |
|---|---|
| Linear formula | CF3C6H4CHO |
| Assay | 98% |
| Density | 1.32 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.466(lit.) |
| Application | 2-(Trifluoromethyl)benzaldehyde has been used in the preparation of:• ω-(dimethylamino)-alkylethyl-4(-2-(trifluorormethyl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates1• methyl (E)-2-[2-[(E)-2-(2-trifluoromethylphenyl)vinyl]-phenyl]-3-methoxyacrylate via Wittig-Horner reaction2 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 61 °C / 141.8 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trifluoromethyl)benzaldehyde used for?
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2-(Trifluoromethyl)benzaldehyde is used as a building block in organic synthesis, particularly in the preparation of pharmaceutical intermediates and complex organic molecules via reactions such as the Wittig-Horner reaction and in the synthesis of dihydropyridine derivatives.
What is the CAS number and chemical formula for 2-(Trifluoromethyl)benzaldehyde?
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The CAS number for 2-(Trifluoromethyl)benzaldehyde is 447-61-0, and its chemical formula is CF3C6H4CHO.
What grade and purity does Tech Serve Solutions supply for 2-(Trifluoromethyl)benzaldehyde?
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Tech Serve Solutions supplies 2-(Trifluoromethyl)benzaldehyde with a purity of 98%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or other pharmacopoeial grades.
How should 2-(Trifluoromethyl)benzaldehyde be handled safely?
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2-(Trifluoromethyl)benzaldehyde is classified as a Warning substance. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and consider using a respirator. Ensure good ventilation and avoid breathing dust/fume/gas/mist/vapours/spray.
Is 2-(Trifluoromethyl)benzaldehyde available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-(Trifluoromethyl)benzaldehyde, serving customers worldwide.
How can I request a sample or quote for 2-(Trifluoromethyl)benzaldehyde?
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To request a sample or quote for 2-(Trifluoromethyl)benzaldehyde, please contact our sales team through the website or provide your details via the enquiry form.
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