2-Bromoisobutanoic acid N-hydroxysuccinimide ester
Tech Serve Solutions offers 2-Bromoisobutanoic acid N-hydroxysuccinimide ester (CAS 728034-24-0), a compound with empirical formula C8H10BrNO4 and molecular weight 264.07 g/mol. This chemical uniquely combines an activated NHS ester for biological conjugation with a bromoisobutyryl moiety, a well-recognised initiator for Atom Transfer Radical Polymerization (ATRP). It serves as a valuable reagent in polymer science and materials research.
- IUPAC
- 1-(2-Bromo-2-methyl-1-oxopropoxy)-2,5-pyrrolidinedione,2,5-Dioxopyrrolidin-1-yl 2-bromo-2-methylpropanoate,2-Bromo-2-methyl-propanoic acid 2,5-dioxo-1-pyrrolidinyl ester,2-Bromoisobutyryl(N-hydroxysuccinimide),N-Hydroxysuccinimidyl 2-bromo-2-methylpropionate,NHS ATRP initiator,NHS protected Bromoisobutyrate,NHS-BiB
- Synonyms
- 2,5-Dioxopyrrolidin-1-yl 2-bromo-2-methylpropanoate2-Bromo-2-methyl-propanoic acid 2,5-dioxo-1-pyrrolidinyl ester2-Bromoisobutyryl(N-hydroxysuccinimide)N-Hydroxysuccinimidyl 2-bromo-2-methylpropionateNHS ATRP initiatorNHS protected BromoisobutyrateNHS-BiB
Atom Transfer Radical Polymerization (ATRP)
This compound functions as an effective initiator for ATRP, enabling controlled synthesis of polymers with defined architectures. The bromoisobutyryl group initiates the radical polymerization process, leading to polymers with predictable molecular weights and low dispersity.
Bioconjugation Chemistry
The N-hydroxysuccinimide (NHS) ester functionality allows for facile conjugation to primary amines. This is useful for labelling biomolecules or creating functionalised surfaces in biochemical and materials science applications.
Materials Science Research
Its dual functionality makes it suitable for advanced materials development, including the synthesis of block copolymers and surface-initiated polymerizations, contributing to innovations in nanotechnology and advanced materials.
| Molecular weight | 264.07 |
|---|---|
| Empirical formula | C8H10BrNO4 |
| Assay | 98% (GC) |
| Storage temperature | 2-8°C |
| Application | The NHS ester is an activated ester commonly used in biological ligation, and the bromoisobutyryl- moiety is commonly used as an initiator in atom transfer radical polymerization (ATRP). |
| Melting point | 135-140 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromoisobutanoic acid N-hydroxysuccinimide ester used for?
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It is primarily used as an initiator for Atom Transfer Radical Polymerization (ATRP) and in bioconjugation chemistry due to its NHS ester functionality.
What is the CAS number and chemical formula for this compound?
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The CAS number is 728034-24-0 and the empirical formula is C8H10BrNO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product with an assay of 98% (GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Bromoisobutanoic acid N-hydroxysuccinimide ester be handled safely?
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This compound is classified as harmful if swallowed and causes skin and eye irritation, and may cause respiratory irritation. Handle with appropriate personal protective equipment in a well-ventilated area. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
How is 2-Bromoisobutanoic acid N-hydroxysuccinimide ester packed, shipped, and exported?
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This product is typically stored at 2-8°C. We adhere to all international shipping and export regulations for chemical compounds.
How can I request a quote or sample?
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Please contact our sales team via the website or by phone to request a quote or to arrange a sample.
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