2-Bromo-4-(trifluoromethyl)pyridine
2-Bromo-4-(trifluoromethyl)pyridine (CAS: 175205-81-9, C6H3BrF3N) is a halogenated pyridine derivative supplied by Tech Serve Solutions. With a molecular weight of 225.99 g/mol, this compound serves as a valuable building block in organic synthesis. Its chemical structure allows for regioselective functionalisation, making it useful in the preparation of more complex molecules, particularly in pharmaceutical and agrochemical research and development.
Synthesis of Nicotinic Acid Derivatives
This compound can undergo regioselective deprotonation at the C-3 position using strong bases like LDA. Subsequent reaction with carbon dioxide yields the corresponding nicotinic acid derivative, a key step in synthesizing various biologically active compounds.
Heterocyclic Building Block
As a halogenated heterocycle, 2-Bromo-4-(trifluoromethyl)pyridine is employed in cross-coupling reactions and other transformations to construct complex molecular architectures. It is a useful intermediate for introducing the trifluoromethylpyridine moiety into target molecules.
Chemical Synthesis Intermediate
Its reactivity profile makes it a versatile intermediate in multi-step organic syntheses. Researchers can utilise the bromine atom for diverse substitution or coupling reactions, while the trifluoromethyl group imparts unique electronic and lipophilic properties.
| Molecular weight | 225.99 |
|---|---|
| Empirical formula | C6H3BrF3N |
| Assay | 97% |
| Boiling point | 84-85 °C/14 mmHg |
| Density | 1.827 g/mL at 25 °C |
| Refractive index | n20/D 1.478 |
| Application | Regioselective deprotonation at C-3 with LDA followed by trapping with carbon dioxide provides the correspondin nicotinic acid.1 |
Hazard statements
- H301Toxic if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Flash point | 73 °C / 163.4 °F |
| Transport (UN / ADR) | UN 2810 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 25-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-4-(trifluoromethyl)pyridine used for?
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2-Bromo-4-(trifluoromethyl)pyridine is primarily used as a building block in organic synthesis, particularly for preparing nicotinic acid derivatives and other complex heterocyclic compounds in pharmaceutical and agrochemical research.
What are the CAS number and molecular formula?
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The CAS number for 2-Bromo-4-(trifluoromethyl)pyridine is 175205-81-9, and its molecular formula is C6H3BrF3N.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-4-(trifluoromethyl)pyridine with an assay of 97%. This product is intended for research and chemical synthesis purposes and is not represented as USP, BP, EP, or pharmaceutical grade.
How should 2-Bromo-4-(trifluoromethyl)pyridine be handled safely?
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This compound is classified as Danger (GHS06). It is harmful if swallowed and causes skin and eye irritation, and may cause respiratory irritation (H301-H315-H319-H335). Always handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator filter (e.g., N95 or P1).
How is 2-Bromo-4-(trifluoromethyl)pyridine packaged and shipped?
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2-Bromo-4-(trifluoromethyl)pyridine is shipped as a UN 2810 (Toxic Solid, Organic, N.O.S.) substance, hazard class 6.1, packing group III. Packaged according to relevant dangerous goods regulations for safe export and handling.
How can I request a quote or sample?
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To request a quote or a sample of 2-Bromo-4-(trifluoromethyl)pyridine, please contact the Tech Serve Solutions sales team through our website or by phone, providing your contact details and desired quantity.
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