2-Bromo-4,5-difluorophenol
2-Bromo-4,5-difluorophenol (CAS: 166281-37-4), a fluorinated aromatic compound with the molecular formula C6H3BrF2O and a molecular weight of 208.99 g/mol. This chemical serves as a valuable building block in organic synthesis, particularly for the introduction of difluorinated phenyl moieties. Its reactivity makes it suitable for various chemical transformations in the development of advanced materials and pharmaceutical intermediates.
- Synonyms
- BrC6H2(F)2OH

Organic Synthesis Intermediate
Utilised as a key intermediate in multi-step organic synthesis pathways. Its specific substitution pattern allows for regioselective reactions in the construction of complex molecules.
Pharmaceutical Research
A useful synthon for researchers developing novel pharmaceutical candidates. The presence of fluorine atoms can impart desirable properties such as increased metabolic stability and lipophilicity.
Material Science
Can be incorporated into the synthesis of advanced materials where fluorinated aromatic structures are required. This may include polymers or specialised electronic materials.
| Molecular weight | 208.99 |
|---|---|
| Linear formula | BrC6H2(F)2OH |
| Assay | 99% |
| Density | 1.829 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.531(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 81 °C / 177.8 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-4,5-difluorophenol used for?
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2-Bromo-4,5-difluorophenol is primarily used as a building block in organic synthesis for creating complex molecules, including intermediates for pharmaceuticals and advanced materials.
What is the CAS number and formula for 2-Bromo-4,5-difluorophenol?
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The CAS number is 166281-37-4, and the linear formula is BrC6H2(F)2OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-4,5-difluorophenol with an assay of 99%. This product is intended for research and chemical synthesis purposes; TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for 2-Bromo-4,5-difluorophenol?
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2-Bromo-4,5-difluorophenol is a Warning substance, with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, is essential during handling. Ensure adequate ventilation.
Is 2-Bromo-4,5-difluorophenol a controlled substance?
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Based on the provided data, there is no indication that 2-Bromo-4,5-difluorophenol is a controlled substance.
How is 2-Bromo-4,5-difluorophenol packed, shipped, and exported?
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2-Bromo-4,5-difluorophenol is typically packed according to industry standards to ensure safe transit. As a global supplier, Tech Serve Solutions exports this chemical worldwide, adhering to all relevant shipping regulations.
How can I request a quote or sample for 2-Bromo-4,5-difluorophenol?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through our website or direct contact details. Specify the product name and CAS number for efficient processing.
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