2,6-Difluorobenzylzinc bromide solution
2,6-Difluorobenzylzinc bromide solution (CAS: 307496-33-9), with a molecular weight of 272.41 g/mol, is a valuable organometallic reagent. Supplied as a 0.5 M solution in THF, it is characterised by its reactive organozinc halide nature. This compound is primarily utilised in organic synthesis, enabling the formation of new carbon-carbon bonds through cross-coupling reactions and other transformations.
- Synonyms
- F2C6H3CH2ZnBr
Cross-Coupling Reactions
2,6-Difluorobenzylzinc bromide solution serves as a versatile nucleophile in various transition-metal catalysed cross-coupling reactions, such as Negishi coupling, for the synthesis of complex organic molecules.
Organozinc Halide Chemistry
As an organozinc halide, this reagent participates in addition reactions to carbonyl compounds and imines, facilitating the introduction of the 2,6-difluorobenzyl moiety into diverse molecular frameworks.
Pharmaceutical Intermediate Synthesis
The compound is instrumental in the construction of fluorinated organic compounds, which are frequently found in active pharmaceutical ingredients due to their altered metabolic stability and binding properties.
Agrochemical Development
Its application extends to the synthesis of novel agrochemicals, where the introduction of fluorine atoms can significantly impact biological activity and environmental persistence.
| Molecular weight | 272.41 |
|---|---|
| Linear formula | F2C6H3CH2ZnBr |
| Density | 0.981 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,6-Difluorobenzylzinc bromide solution used for?
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2,6-Difluorobenzylzinc bromide solution is used in organic synthesis, particularly in cross-coupling reactions and for introducing the 2,6-difluorobenzyl group into molecules, finding applications in the synthesis of pharmaceutical intermediates and agrochemicals.
What are the CAS number and formula for 2,6-Difluorobenzylzinc bromide solution?
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The CAS number is 307496-33-9, and the linear formula is F₂C₆H₃CH₂ZnBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. TSS does not represent this product as USP, BP, or EP grade.
What are the key safety and handling considerations for this product?
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This product is highly flammable (flash point -17 °C) and an irritant. It may form explosive peroxides. Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources. Refer to the Safety Data Sheet for detailed information.
How is 2,6-Difluorobenzylzinc bromide solution packed, shipped, and exported?
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This product is typically packed according to UN 2924 regulations for flammable liquids, corrosive liquids, and toxic substances, shipping under PGII. We expertly manage global export logistics.
How can I request a sample or quote for 2,6-Difluorobenzylzinc bromide solution?
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To request a sample or quote, please contact our sales team via the website or provide your details through the online inquiry form, specifying the product and desired quantity.
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