1-Chloro-2,5-difluorobenzene
1-Chloro-2,5-difluorobenzene (CAS: 2367-91-1), with the molecular formula ClC6H3F2 and a molecular weight of 148.54 g/mol, is a halogenated aromatic compound. It functions as a valuable building block in organic synthesis, particularly for the preparation of fluorinated cyclic compounds. Its properties make it suitable for chemical synthesis applications requiring specific halogenated aromatic precursors.
- Synonyms
- ClC6H3F2

Synthesis of Fluorocyclohexadienes
This compound serves as a precursor in the synthesis of fluorocyclohexadienes through electrochemical fluorination processes. This application highlights its utility in creating complex fluorinated organic molecules.
Organic Building Block
As a halogenated aromatic, 1-Chloro-2,5-difluorobenzene is a versatile building block for constructing more complex organic molecules. It is employed in chemical synthesis where the introduction of a difluorophenyl moiety is desired.
Research and Development
Utilised in research laboratories for the development of novel chemical entities and synthetic methodologies. Its specific structure allows for diverse reaction pathways in advanced organic chemistry.
| Molecular weight | 148.54 |
|---|---|
| Linear formula | ClC6H3F2 |
| Assay | 98% |
| Boiling point | 126-128 °C(lit.) |
| Density | 1.352 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.478(lit.) |
| Application | Used for the synthesis of fluorocyclohexadienes by electrochemical fluorination.1 |


Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 20 °C / 68 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 10-20/21/22-36/37 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Chloro-2,5-difluorobenzene used for?
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1-Chloro-2,5-difluorobenzene is used as a building block in organic synthesis, notably for preparing fluorocyclohexadienes via electrochemical fluorination. It is also used in research and development for creating novel chemical entities.
What is the CAS number and formula for 1-Chloro-2,5-difluorobenzene?
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The CAS number is 2367-91-1, and the linear formula is ClC6H3F2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Chloro-2,5-difluorobenzene with a purity of 98%. We do not represent this product as USP, BP, or EP grade.
How should 1-Chloro-2,5-difluorobenzene be handled safely?
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1-Chloro-2,5-difluorobenzene is a flammable liquid and vapour, and it is harmful if swallowed, in contact with skin, or if inhaled. It also causes serious eye irritation and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, is required. Handle in a well-ventilated area away from ignition sources.
Is 1-Chloro-2,5-difluorobenzene exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 1-Chloro-2,5-difluorobenzene.
How can I request a quote or sample?
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To request a quote or sample of 1-Chloro-2,5-difluorobenzene, please contact our sales team through the website or by phone.
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