Wortmannin
Wortmannin (CAS: 19545-26-7; C23H24O8; MW: 428.43) is a potent, irreversible inhibitor of phosphoinositide 3-kinases (PI3Ks) and phosphatidylinositol 4,5-bisphosphate 3-kinase. Derived from the fungus Penicillium funiculosum, this off-white powder is a crucial tool in cell biology research for investigating PI3K signaling pathways. Its primary application lies in understanding cellular processes regulated by PI3K, including cell growth, proliferation, differentiation, and survival. Wortmannin is invaluable for studying autophagy and cancer research.
- IUPAC
- KY 12420
PI3K Inhibition Studies
Wortmannin serves as a highly effective tool for irreversibly inhibiting PI3K isoforms, allowing researchers to elucidate the specific roles of these enzymes in various cellular signaling cascades.
Autophagy Research
As a potent PI3K inhibitor, wortmannin is widely used to induce or study the process of autophagy, a critical cellular degradation mechanism.
Cancer Cell Signaling
Its ability to block PI3K pathways makes wortmannin valuable for investigating aberrant signaling in cancer cells and exploring potential therapeutic strategies.
Cell Biology Research
This compound aids in exploring fundamental cell biology, including cell growth, survival, and differentiation, by modulating PI3K-dependent pathways.
| Molecular weight | 428.43 |
|---|---|
| Empirical formula | C23H24O8 |
| Assay | ≥98% (HPLC and TLC) |
| Form | powder |
| Colour | off-white |
| Solubility | DMSO: solubleH2O: unstable |
| Storage temperature | 2-8°C |
| Biological source | from Penicillium funiculosum |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3462 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 28-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|---|
| Gene Information | human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Wortmannin used for?
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Wortmannin is primarily used as a research tool to inhibit phosphoinositide 3-kinases (PI3Ks) and investigate cellular processes such as autophagy, cell growth, and cancer signaling.
What is the CAS number and formula for Wortmannin?
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The CAS number for Wortmannin is 19545-26-7, and its molecular formula is C23H24O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Wortmannin at a minimum purity of 98% (HPLC and TLC), suitable for research purposes. It is not supplied as USP, BP, or EP grade.
How should Wortmannin be handled safely?
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Wortmannin is classified as acutely toxic by ingestion, skin contact, and inhalation (Danger; H300-H310-H330). Handle with extreme care using appropriate personal protective equipment including eyeshields, gloves, and respiratory protection (N100/P3).
How is Wortmannin supplied and exported?
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Wortmannin is supplied as an off-white powder. Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a sample or quote for Wortmannin?
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Please contact our sales team via our website or by phone to request a sample or a quote for Wortmannin.
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