(Trimethylsilyl)methylmagnesium chloride solution
(Trimethylsilyl)methylmagnesium chloride solution (CAS: 13170-43-9) is an organometallic reagent featuring a magnesium-carbon bond. Its linear formula is (CH3)3SiCH2MgCl, and it has a molecular weight of 146.97 g/mol. This compound serves as a valuable reagent in organic synthesis, particularly in various nickel-catalyzed reactions such as alkenation of dithioacetals and cross-coupling reactions with aryl triflates, carbamates, and vinyl selenides.
Alkenation of Dithioacetals
This reagent is utilised in nickel-catalyzed alkenation reactions involving dithioacetals, a transformation crucial for constructing carbon-carbon bonds in organic synthesis.
Cross-Coupling Reactions
It participates in cross-coupling reactions with aryl triflates and carbamates, serving as a key nucleophile in these palladium or nickel-catalysed bond-forming processes.
Vinyl Selenide Coupling
The compound is employed in cross-coupling reactions with vinyl selenides, facilitating the formation of new carbon-carbon bonds in complex molecule synthesis.
| Molecular weight | 146.97 |
|---|---|
| Linear formula | (CH3)3SiCH2MgCl |
| Density | 0.777 g/mL at 25 °C |
| Concentration | 1.0 M in diethyl ether |
| Application | Reagent used in a variety of nickel catalyzed reactions including alkenation of dithioacetals,1 cross-coupling with aryl triflates and carbamates,2 and cross-coupling with vinyl selenides.3 |
Hazard statements
- H225Highly flammable liquid and vapour
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
- H336May cause drowsiness or dizziness
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -40 °C / -40 °F |
| Transport (UN / ADR) | UN 3399 4.3/PG 1 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-22-34-67 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Trimethylsilyl)methylmagnesium chloride solution used for?
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(Trimethylsilyl)methylmagnesium chloride solution is used as a reagent in various nickel-catalyzed reactions, including the alkenation of dithioacetals, cross-coupling with aryl triflates and carbamates, and cross-coupling with vinyl selenides.
What is the CAS number and chemical formula?
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The CAS number is 13170-43-9, and the linear chemical formula is (CH3)3SiCH2MgCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (Trimethylsilyl)methylmagnesium chloride solution at a concentration of 1.0 M in diethyl ether. TSS does not represent this product as USP/BP/EP or other pharmacopoeial grades.
What are the main hazards associated with this chemical?
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This product is highly flammable (H225) and can cause severe skin burns and eye damage (H314). It is harmful if swallowed (H302) and may cause drowsiness or dizziness (H336). It reacts violently with water and may form explosive peroxides.
How is this product packed, shipped, and exported?
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As a specialist global supplier, Tech Serve Solutions expertly handles the packing, shipping, and export of (Trimethylsilyl)methylmagnesium chloride solution, adhering to all relevant regulations for hazardous materials.
How can I request a sample or quote?
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To request a sample or a quotation for (Trimethylsilyl)methylmagnesium chloride solution, please use the contact form on our website or call our sales department directly.
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