Trimethyloxonium tetrafluoroborate
Trimethyloxonium tetrafluoroborate (CAS 420-37-1), with the linear formula (CH3)3O(BF4) and a molecular weight of 147.91 g/mol, is a potent methylating agent. It is primarily employed as a reagent in organic synthesis for the methylation of hydroxyl groups. This compound has been recently utilised in sophisticated, multi-step synthetic pathways, including the preparation of complex natural products like spirastrellolide.
Methylation of Hydroxyl Groups
Trimethyloxonium tetrafluoroborate serves as an effective reagent for the methylation of hydroxyl functionalities in organic molecules. This reaction is crucial in various synthetic strategies requiring selective O-methylation.
Complex Natural Product Synthesis
The reagent has been employed in advanced synthetic routes, notably in the multistep preparation of spirastrellolide, a marine-derived natural product, highlighting its utility in complex molecule construction.
Organic Synthesis Reagent
As a versatile synthetic reagent, it facilitates C-X bond formation, particularly in non-halogenated pathways. Its application extends to general chemical synthesis and as a valuable tool for synthetic chemists.
| Molecular weight | 147.91 |
|---|---|
| Linear formula | (CH3)3O(BF4) |
| Assay | ≥98.0% (T) |
| Storage temperature | 2-8°C |
| Application | Reagent for the methylation of hydroxyl groups recently used in a complex, multistep synthesis directed towards spirastrellolide, a marine natural product.1 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-43-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Trimethyloxonium tetrafluoroborate used for?
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Trimethyloxonium tetrafluoroborate is primarily used as a reagent for the methylation of hydroxyl groups in organic synthesis, including complex multistep syntheses of natural products.
What is the CAS number and formula for Trimethyloxonium tetrafluoroborate?
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The CAS number is 420-37-1 and the linear formula is (CH3)3O(BF4).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Trimethyloxonium tetrafluoroborate with a purity of ≥98.0% (T). This is a technical grade reagent and is not represented as USP, BP, or EP.
How should Trimethyloxonium tetrafluoroborate be handled safely?
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Trimethyloxonium tetrafluoroborate is a dangerous substance that reacts violently with water. Handle with extreme care, wearing appropriate personal protective equipment including eyeshields, face shields, and suitable gloves. Ensure adequate ventilation and avoid contact with water. Refer to the Safety Data Sheet for comprehensive handling procedures.
How is this product packed, shipped, and exported?
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This product is packed and shipped in compliance with international regulations for hazardous materials, including UN 3261 classification (Corrosive liquid, acidic, organic, n.o.s., 8, PGII). TSS exports globally, adhering to all relevant shipping and customs requirements.
How can I request a sample or quote for Trimethyloxonium tetrafluoroborate?
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To request a sample or a quote, please contact our sales department through the website or by calling us. Please specify the quantity and delivery location.
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